Evidence map›Paper›PMID 38504005›Full record

ArticleNeuromolecular medicine2024

Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer's Disease.

Limin Ma, Fengyu Wang, Shuai Chen, Shenghui Wang, Zhenzhen Wang, Mingrong Xia, Yongli Li, Huimin Ma, Junkui Shang, Jiewen Zhang

Abstract read
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In one paragraph

Article in Neuromolecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Limin MaDepartment of Health Management Center, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Fengyu WangDepartment of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Shuai ChenDepartment of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Shenghui WangDepartment of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhenzhen WangDepartment of Radiology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Mingrong XiaDepartment of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yongli LiDepartment of Health Management Center, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Huimin MaDepartment of Health Management Center, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Junkui ShangDepartment of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Jiewen ZhangDepartment of Neurology, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China. zhangjiewen9900@126.com.
Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Familial Alzheimer's disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid precursor protein), PSEN1 (encoding presenilin 1), and PSEN2 (encoding presenilin 2) are the most common genes cause dominant inherited AD. This study aimed to demonstrate a Chinese early-onset AD pedigree presenting as progressive memory impairment, apraxia, visual-spatial disorders, psychobehavioral disorders, and personality changes with a novel APP gene mutation. The family contains four patients, three carries and three normal family members. The proband underwent brain magnetic resonance imaging (MRI),

Indexed as

Alzheimer DiseaseAniline CompoundsEthylene GlycolsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorChinaFluorodeoxyglucose F18HumansMutationPresenilin-1Amyloid beta-PeptidesAmyloid beta-Protein PrecursorAniline CompoundsEthylene GlycolsflorbetapirFluorodeoxyglucose F18Presenilin-1Alzheimer’s diseaseAPPBiomarkerEOAD

Identifiers

PMID38504005
OpenAlexW4392947094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.