ArticleNature microbiology2024
Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition.
Open access · hybridAbstract readEvaluation Study
In one paragraph
Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 44 citations in OpenAlex.
- A microbiome-directed therapeutic food for children recovering from severe acute malnutrition.Science translational medicine · 2024Trial
- A microbiota-directed complementary food intervention in 12-18-month-old Bangladeshi children improves linear growth.EBioMedicine · 2024Trial
- Towards optimizing the host response to biotics: a report of an International Scientific Association for Probiotics and Prebiotics working group.Gut microbes · 2026Article
- Host-microbiome interactions and enteric pathogen infections-from early-life to long-term impacts on gut-brain communication.Journal of applied microbiology · 2026Review
- Article
- Reply to Wang et al.: Linking microbial metabolites and gut epithelial responses to microbiome-directed therapeutic foods.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Gut microbiome associations with acute malnutrition relapse in South Sudan.Microbiology spectrum · 2026Article
- Enhancing inference of differential gene expression in metatranscriptomes from human microbial communities.Nature communications · 2026Article
- High-resolution metagenome assembly for modern long reads with myloasm.Nature biotechnology · 2026Article
- Gut microbiota drives the metabolic dysregulation in obesity-prone individuals by impairing GDCA-mediated activation of brown adipose thermogenesis and ileal GLP-1 secretion.Acta pharmaceutica Sinica. B · 2026Article
- Simiao Decoction alleviates hyperuricemia-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins.NPJ biofilms and microbiomes · 2026Article
- Early life nutritional imbalance impairs colonic epithelial regeneration through gut microbiota dysbiosis and metabolic suppression.The ISME journal · 2026Article
- Disrupting the vicious cycle of malnutrition and enteropathy: advancing strategies to improve child physical and neurocognitive outcomes.Frontiers in public health · 2026Review
- Gut Microbiota Diversity and Function in Adults With Type 2 Diabetes, Alzheimer's Disease, and Both Conditions.International journal of microbiology · 2026Article
- Glycoside hydrolase-mediated glucomannan catabolism inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Using gnotobiotic mice to decipher effects of gut microbiome repair in undernourished children on tuft and goblet cell function.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effects of intergenerational transmission of small intestinal bacteria cultured from stunted Bangladeshi children with enteropathy.bioRxiv : the preprint server for biology · 2025Article
- Analyzing human gut microbiome data from global populations: challenges and resources.Trends in microbiology · 2025Review
- Using gnotobiotic mice to decipher effects of gut microbiome repair in undernourished children on tuft and goblet cell function.bioRxiv : the preprint server for biology · 2025Article
- Systematic evaluation of metatranscriptomic differential gene expressionbioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
32 authors at 7 institutions in 5 countries.
Hao-Wei Chang *Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-1160-7452
Evan M Lee *Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Yi Wang *Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Cyrus ZhouEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-4335-6894
Kali M PrussEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-8619-5886
Suzanne HenrissatEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Robert Y ChenEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Clara KaoEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-2210-5447
Matthew C HibberdEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6520-677X
Hannah M LynnEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6063-5820
Daniel M WebberEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6109-8118
Marie CraneEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-5090-2163
Jiye ChengEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0266-3997
Dmitry A RodionovInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Aleksandr A ArzamasovInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-4150-4817
Juan J CastilloDepartment of Chemistry, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-9680-5273
Garret CoutureDepartment of Chemistry, University of California, Davis, CA, USA.
Ye ChenEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6379-1968
Nikita P BalcazoDepartment of Chemistry, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0002-6253-6340
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-7190-5323
Nicolas TerraponArchitecture et Fonction des Macromolécules Biologiques, CNRS, Aix-Marseille University, Marseille, France.ORCID http://orcid.org/0000-0002-3693-6017
Bernard HenrissatDepartment of Biotechnology and Biomedicine (DTU Bioengineering), Technical University of Denmark, Lyngby, Denmark.ORCID http://orcid.org/0000-0002-3434-8588
Olga IlkayevaSarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0002-9779-0883
Michael J MuehlbauerSarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.
Christopher B NewgardSarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0002-1293-691X
Ishita MostafaInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Subhasish DasInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Mustafa MahfuzInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Andrei L OstermanInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3810-9824
Michael J BarrattEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Tahmeed AhmedInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Jeffrey I GordonEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA. jgordon@wustl.edu.ORCID http://orcid.org/0000-0001-8304-3548
Washington University in St. Louis · USInternational Centre for Diarrhoeal Disease Research · BDUniversity of California, Davis · USDuke University · USSanford Burnham Prebys Medical Discovery Institute · USCentre National de la Recherche Scientifique · FRKing Abdulaziz University · SA
Funding
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MDIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7MINSTITUTIONAL TRAINING GRANT IN GENOMIC SCIENCET32HG000045 · NHGRI · WASHINGTON UNIVERSITY · PI MICHAEL R BRENT, Barak A Cohen · 1997 to 2026
$8.4MREGULATION OF GENE EXPRESSION - SMALL INTESTINER01DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI JEFFREY I GORDON, ANDREI L OSTERMAN · 1986 to 2026
$6.5MREGULATION OF GENE EXPRESSION IN THE SMALL INTESTINER37DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 1993 to 2015
$4.0MKey gut microbes shape intestinal epithelial lineage development, differentiation and metabolic functionK01DK134840 · NIDDK · WASHINGTON UNIVERSITY · PI Yi Wang · 2023 to 2026
$571kMechanism of action of a microbiota-directed complementary food that promotes ponderal growth in Bangladeshi children with moderate acute malnutritionF30DK131866 · NIDDK · WASHINGTON UNIVERSITY · PI ZHOU, CYRUS · 2022 to 2024
$138kImpact of Gut Bacterial Interactions on the Response to Fiber-Based PrebioticsF30DK123838 · NIDDK · WASHINGTON UNIVERSITY · PI BELLER, ZACHARY WALTER · 2020 to 2022
$127kNHGRI NIH HHS T32 HG000045NIDDK NIH HHS F30 DK123838NIDDK NIH HHS F30 DK131866NIDDK NIH HHS K01 DK134840NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK030292NIDDK NIH HHS R37 DK030292NIDDK NIH HHS T32 DK007120NIGMS NIH HHS T32 GM007200
Abstract
Microbiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, improved weight gain in malnourished Bangladeshi children compared to a more calorically dense standard nutritional intervention. Metagenome-assembled genomes from study participants revealed a correlation between ponderal growth and expression of MDCF-2 glycan utilization pathways by Prevotella copri strains. To test this correlation, here we use gnotobiotic mice colonized with defined consortia of age- and ponderal growth-associated gut bacterial strains, with or without P. copri isolates closely matching the metagenome-assembled genomes. Combining gut metagenomics and metatranscriptomics with host single-nucleus RNA sequencing and gut metabolomic analyses, we identify a key role of P. copri in metabolizing MDCF-2 glycans and uncover its interactions with other microbes including Bifidobacterium infantis. P. copri-containing consortia mediated weight gain and modulated energy metabolism within intestinal epithelial cells. Our results reveal structure-function relationships between MDCF-2 and members of the gut microbiota of malnourished children with potential implications for future therapies.
Indexed as
Gastrointestinal MicrobiomeMalnutritionMicrobiotaPrevotellaAnimalsMiceWeight Gain
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