Evidence map›Paper›PMID 38503921›Full record

ReviewJournal of cancer research and clinical oncology2024

Large language models as decision aids in neuro-oncology: a review of shared decision-making applications.

Aaron Lawson McLean, Yonghui Wu, Anna C Lawson McLean, Vagelis Hristidis

Abstract readReview
In one paragraph

Review in Journal of cancer research and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. AI in Medical Questionnaires: Scoping ReviewJournal of medical Internet research · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Evidence-Based Analysis of AI Chatbots in Oncology Patient Education: Implications for Trust, Perceived Realness, and Misinformation Management.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025
    Review
  6. Article
  7. Review
  8. Fine-Tuning Large Language Models for Specialized Use Cases.Mayo Clinic proceedings. Digital health · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aaron Lawson McLeanDepartment of Neurosurgery, Jena University Hospital-Friedrich Schiller University Jena, Am Klinikum 1, 07747, Jena, Germany. aaron.lawsonmclean@med.uni-jena.de.ORCID http://orcid.org/0000-0001-5528-6905
Yonghui WuDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-6780-6135
Anna C Lawson McLeanDepartment of Neurosurgery, Jena University Hospital-Friedrich Schiller University Jena, Am Klinikum 1, 07747, Jena, Germany.ORCID http://orcid.org/0000-0002-3146-4241
Vagelis HristidisComputer Science and Engineering, University of California, Riverside, Riverside, CA, USA.ORCID http://orcid.org/0000-0001-8679-4988

Funding

Advancing Drug Repositioning for Alzheimer’s Disease using Real-world DataR56AG069880 · NIA · UNIVERSITY OF FLORIDA · PI BIAN, JIANG, CHEN, YONG · 2021 to 2022
$1.6M
NIA NIH HHS R56 AG069880NIA NIH HHS R56AG069880Patient-Centered Outcomes Research Institute ME-2018C3-14754
6 · The paper itself

Abstract

Shared decision-making (SDM) is crucial in neuro-oncology, fostering collaborations between patients and healthcare professionals to navigate treatment options. However, the complexity of neuro-oncological conditions and the cognitive and emotional burdens on patients present significant barriers to achieving effective SDM. This discussion explores the potential of large language models (LLMs) such as OpenAI's ChatGPT and Google's Bard to overcome these barriers, offering a means to enhance patient understanding and engagement in their care. LLMs, by providing accessible, personalized information, could support but not supplant the critical insights of healthcare professionals. The hypothesis suggests that patients, better informed through LLMs, may participate more actively in their treatment choices. Integrating LLMs into neuro-oncology requires navigating ethical considerations, including safeguarding patient data and ensuring informed consent, alongside the judicious use of AI technologies. Future efforts should focus on establishing ethical guidelines, adapting healthcare workflows, promoting patient-oriented research, and developing training programs for clinicians on the use of LLMs. Continuous evaluation of LLM applications will be vital to maintain their effectiveness and alignment with patient needs. Ultimately, this exploration contends that the thoughtful integration of LLMs into SDM processes could significantly enhance patient involvement and strengthen the patient-physician relationship in neuro-oncology care.

Indexed as

Health PersonnelInformed ConsentDecision Support TechniquesHumansLanguagePatient ParticipationEthical considerationsHealthcare integrationLarge language modelsNeuro-oncology carePatient engagementShared decision making

Identifiers

PMID38503921
PMCPMC10951032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.