Evidence map›Paper›PMID 38503819›Full record

ArticleScientific reports2024

Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model.

Tamás Marosvölgyi, Kitti Mintál, Nelli Farkas, Zoltán Sipos, Lilla Makszin, Éva Szabó, Attila Tóth, Béla Kocsis, Krisztina Kovács, Edina Hormay and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Nutrients · 2025
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Tamás Marosvölgyi *Institute of Bioanalysis, Medical School, University of Pécs, Pécs, 7624, Hungary.
Kitti Mintál *Institute of Physiology, Medical School, University of Pécs, Pécs, 7624, Hungary.
Nelli FarkasInstitute of Bioanalysis, Medical School, University of Pécs, Pécs, 7624, Hungary.
Zoltán SiposInstitute of Bioanalysis, Medical School, University of Pécs, Pécs, 7624, Hungary.
Lilla MakszinInstitute of Bioanalysis, Medical School, University of Pécs, Pécs, 7624, Hungary.
Éva SzabóDepartment of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Pécs, 7624, Hungary. szabo.eva.dr@pte.hu.
Attila TóthInstitute of Physiology, Medical School, University of Pécs, Pécs, 7624, Hungary.
Béla KocsisDepartment of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, 7624, Hungary.
Krisztina KovácsDepartment of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, 7624, Hungary.
Edina HormayInstitute of Physiology, Medical School, University of Pécs, Pécs, 7624, Hungary.
László LénárdInstitute of Physiology, Medical School, University of Pécs, Pécs, 7624, Hungary.
Zoltán KarádiInstitute of Physiology, Medical School, University of Pécs, Pécs, 7624, Hungary.
Anita BufaInstitute of Bioanalysis, Medical School, University of Pécs, Pécs, 7624, Hungary.
University of Pecs · HU

Funding

Magyarország Kormánya EFOP-3.6.1- 16-2016-00004Magyarország Kormánya TKP2University of Pecs Proof of Principle PTE/101413-1/2019
6 · The paper itself

Abstract

Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes on the detailed FA spectrum has not been explored yet. We investigated the effect of antibiotics (ABx) and/or probiotics, in four treatment groups on rat stool FA composition. Principal component analysis indicated that the chromatogram profiles of the treatment groups differ, which was also observed at different time points. Linear mixed effects models showed that in the parameters compared (sampling times, treatments. and their interactions), both the weight percentage and the concentration of FAs were affected by ABx and probiotic administration. This study found that the gut microbiome defines trans and branched saturated FAs, most saturated FAs, and unsaturated FAs with less carbon atoms. These results are among the first ones to demonstrate the restoring effects of a probiotic mixture on a substantial part of the altered total FA spectrum, and also revealed a previously unknown relationship between gut bacteria and a larger group of FAs. These findings suggest that intestinal bacteria produce not only SCFAs but also other FAs that may affect the host's physiological processes.

Indexed as

Fatty AcidsProbioticsAnimalsAnti-Bacterial AgentsBacteriaFatty Acids, UnsaturatedFatty Acids, VolatileFecesRatsAnti-Bacterial AgentsFatty AcidsFatty Acids, UnsaturatedFatty Acids, Volatile

Identifiers

PMID38503819
PMCPMC10951306
OpenAlexW4392960011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.