Observational studyCirculation. Cardiovascular imaging2024
Cardiac Magnetic Resonance to Predict Cardiac Mass Malignancy: The CMR Mass Score.
Observational study in Circulation. Cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- [European journal of nuclear medicine and molecular imaging · 2025Pooled it
- Detection of cardiac neuroendocrine tumour metastases by somatostatin receptor PET/CT: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- The Dangerous Liaison Between Depression and Cardiovascular Disease: A Narrative Review of Epidemiology, Mechanisms, and Clinical Management.Journal of clinical medicine · 2026Review
- Small but lethal: cystic tumour of the atrioventricular node-a case report.European heart journal. Case reports · 2026Article
- Cardiac Incidentalomas in the Trauma Bay: Imaging Beyond the Red Herring.JACC. Case reports · 2026Article
- Rare Late Cardiac Involvement Following Resected Primary Limb Dedifferentiated Liposarcoma: A Case Report.Clinical case reports · 2026Article
- Multiparametric cardiovascular magnetic resonance for differentiating cardiac masses: clinical impact from a case series.European heart journal. Case reports · 2026Article
- A Rare Intracardiac Manifestation of an Aggressive Malignant Peripheral Nerve Sheath Tumor in a Young Adult.CASE (Philadelphia, Pa.) · 2026Article
- When Palpitations Unmask Crista Terminalis Hypertrophy: A Case Report and Review of Current Literature.Diagnostics (Basel, Switzerland) · 2026Article
- Prevalence, characteristics, and surgical outcomes of cardiac masses: a 6-year retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Non-Small-Cell Lung Cancer: From Histopathological Classification to Precision Oncology-A Narrative Review.Journal of clinical medicine · 2026Review
- Multimodality imaging of the right ventricular outflow tract haemangioma requiring pulmonary valve replacement.European heart journal. Case reports · 2026Article
- Review
- Multimodality Imaging in Cardiac Metastasis of Cutaneous Melanoma: Case Report and Systematic Review.Journal of cardiovascular development and disease · 2026Article
- Multimodal echocardiographic techniques in the diagnosis of cardiac tumors: applications and recent advances.Frontiers in cardiovascular medicine · 2026Review
- Case Report: Adjuvant radiation therapy for cardiac intimal sarcoma with long-term disease control.Frontiers in oncology · 2026Article
- 1-Month Relapse of Undifferentiated Sarcoma in the Left Atrium.JACC. Case reports · 2025Article
- Cardiac Angiosarcoma in a 17-Year-Old Female: A Rare Case Report and Literature Review.Cureus · 2025Article
- A Dynamic Multimodality Imaging Assessment of Right Ventricular Thrombosis in a Middle-Aged Man with Lymphocytic Interstitial Pneumonia: The Additive Role of Tissue Doppler Imaging.Journal of clinical medicine · 2025Article
- Development and validation of a novel echocardiography-based nomogram for the streamlined classification of cardiac tumors in cancer patients.Quantitative imaging in medicine and surgery · 2025Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
27 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultimodality imaging is currently suggested for the noninvasive diagnosis of cardiac masses. The identification of cardiac masses' malignant nature is essential to guide proper treatment. We aimed to develop a cardiac magnetic resonance (CMR)-derived model including mass localization, morphology, and tissue characterization to predict malignancy (with histology as gold standard), to compare its accuracy versus the diagnostic echocardiographic mass score, and to evaluate its prognostic ability.
methodsObservational cohort study of 167 consecutive patients undergoing comprehensive echocardiogram and CMR within 1-month time interval for suspected cardiac mass. A definitive diagnosis was achieved by histological examination or, in the case of cardiac thrombi, by histology or radiological resolution after adequate anticoagulation treatment. Logistic regression was performed to assess CMR-derived independent predictors of malignancy, which were included in a predictive model to derive the CMR mass score. Kaplan-Meier curves and Cox regression were used to investigate the prognostic ability of predictors.
resultsIn CMR, mass morphological features (non-left localization, sessile, polylobate, inhomogeneity, infiltration, and pericardial effusion) and mass tissue characterization features (first-pass perfusion and heterogeneity enhancement) were independent predictors of malignancy. The CMR mass score (range, 0-8 and cutoff, ≥5), including sessile appearance, polylobate shape, infiltration, pericardial effusion, first-pass contrast perfusion, and heterogeneity enhancement, showed excellent accuracy in predicting malignancy (areas under the curve, 0.976 [95% CI, 0.96-0.99]), significantly higher than diagnostic echocardiographic mass score (areas under the curve, 0.932;
conclusionsA CMR-derived model, including mass morphology and tissue characterization, showed excellent accuracy, superior to echocardiography, in predicting cardiac masses malignancy, with prognostic implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.