ArticleProceedings of the National Academy of Sciences of the United States of America2024
The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Feeding a Diurnal Rodent at Night Induces Weight Loss and Body Temperature Reduction Without Food-Anticipatory Activity.Journal of biological rhythms · 2026Article
- A novel circadian behavior rhythm in arrhythmiciScience · 2025Article
- Tracking conditioned fear in pair-housed mice using deep learning and real-time cue delivery.Neurobiology of stress · 2025Article
- A stress-sensing circuit signals to the central pacemaker to reprogram circadian rhythms.Science advances · 2025Article
- Daytime aversive stimuli do not phase shift behavioral rhythms under light-dark cycles in a strictly diurnal rodent.Journal of biological rhythms · 2025Article
- Multiple oscillators underlie circadian food anticipation in mice.Neurobiology of sleep and circadian rhythms · 2025Article
- Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025Review
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10 authors.
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Abstract
We show that nocturnal aversive stimuli presented to mice while they are eating and drinking outside of their safe nest can entrain circadian behaviors, leading to a shift toward daytime activity. We also show that the canonical molecular circadian clock is necessary for fear entrainment and that an intact molecular clockwork in the suprachiasmatic nucleus, the site of the central circadian pacemaker, is necessary but not sufficient to sustain fear entrainment of circadian rhythms. Our results demonstrate that entrainment of a circadian clock by cyclic fearful stimuli can lead to severely mistimed circadian behavior that persists even after the aversive stimulus is removed. Together, our findings support the interpretation that circadian and sleep symptoms associated with fear and anxiety disorders are, in part, the output of a fear-entrained clock, and provide a mechanistic insight into this clock.
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