Evidence map›Paper›PMID 38502692›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Tapered chiral nanoparticles as broad-spectrum thermally stable antivirals for SARS-CoV-2 variants.

Rui Gao, Xinxin Xu, Prashant Kumar, Ye Liu, Hongyu Zhang, Xiao Guo, Maozhong Sun, Felippe Mariano Colombari, André F de Moura, Changlong Hao and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Rui Gao *International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.ORCID 0009-0003-2192-2303
Xinxin Xu *International Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
Prashant Kumar *Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109.
Ye LiuInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan 650000, People's Republic of China.
Hongyu ZhangInternational Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
Xiao GuoInternational Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
Maozhong SunInternational Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
Felippe Mariano ColombariBrazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, São Paulo 13083-100, Brazil.
André F de MouraDepartment of Chemistry, Federal University of São Carlos, São Carlos, São Paulo 13565-905, Brazil.ORCID 0000-0003-1974-4803
Changlong HaoInternational Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
Jessica MaDepartment of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109.
Emine Sumeyra Turali EmreDepartment of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-8166-0892
Minjeong ChaDepartment of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-8721-7111
Liguang XuInternational Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
Hua KuangInternational Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.ORCID 0000-0002-2724-8722
Nicholas A KotovDepartment of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-6864-5804
Chuanlai XuInternational Joint Research Laboratory for Biointerface and Biodetection, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.ORCID 0000-0002-5639-7102
Jiangnan University · CNUniversity of Michigan · USBrazilian Center for Research in Energy and Materials · BRChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversidade Federal de São Carlos · BR

Funding

MOST | National Natural Science Foundation of China (NSFC) 21977038National Science Foundation (NSF) 1566460
6 · The paper itself

Abstract

The incessant mutations of viruses, variable immune responses, and likely emergence of new viral threats necessitate multiple approaches to novel antiviral therapeutics. Furthermore, the new antiviral agents should have broad-spectrum activity and be environmentally stable. Here, we show that biocompatible tapered CuS nanoparticles (NPs) efficiently agglutinate coronaviruses with binding affinity dependent on the chirality of surface ligands and particle shape.

Indexed as

Coronavirus OC43, HumanCOVID-19AnimalsAntibodiesAntiviral AgentsHumansMiceSARS-CoV-2AntibodiesAntiviral Agentsbiomimeticcapsidschiral nanoparticlesself-assemblysupraparticles

Identifiers

PMID38502692
PMCPMC10990083
OpenAlexW4392946453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.