Evidence map›Paper›PMID 38502690›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Glucuronic acid confers colonization advantage to enteric pathogens.

Thibaut Rosay, Angel G Jimenez, Vanessa Sperandio

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Chondroitin sulfate degradation bolstersbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Thibaut RosayDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0001-6945-4850
Angel G JimenezDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Vanessa SperandioDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-0819-7904
University of Wisconsin–Madison · USThe University of Texas Southwestern Medical Center · US

Funding

Quorum sensing regulation of EHEC virulence genesR01AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2003 to 2017
$6.3M
Quorum Sensing Regulation of EHEC Virulence GenesR37AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VANESSA SPERANDIO · 2018 to 2026
$5.3M
Sugar regulation of EHEC virulenceR01AI154597 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MARESSO, ANTHONY W, SPERANDIO, VANESSA · 2020 to 2024
$3.1M
Tryptophan derivatives in EHEC pathogenesisR01AI155398 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2021 to 2025
$3.0M
NIAID NIH HHS R01 AI053067NIAID NIH HHS R01 AI154597NIAID NIH HHS R01 AI155398NIAID NIH HHS R37 AI053067
6 · The paper itself

Abstract

Glucuronidation is a detoxification process to eliminate endo- and xeno-biotics and neurotransmitters from the host circulation. Glucuronosyltransferase binds these compounds to glucuronic acid (GlcA), deactivating them and allowing their elimination through the gastrointestinal (GI) tract. However, the microbiota produces β-glucuronidases that release GlcA and reactivate these compounds. Enteric pathogens such as enterohemorrhagic

Indexed as

Escherichia coli InfectionsMicrobiotaAnimalsEscherichia coliGlucuronic AcidMiceVirulenceGlucuronic AcidCitrobacter rodentiumenteric pathogensglucuronic acidmicrobiota glucuronidase

Identifiers

PMID38502690
PMCPMC10990124
OpenAlexW4392946600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.