Evidence map›Paper›PMID 38502687›Full record

ArticleSTAR protocols2024

Protocol for fast clonal family inference and analysis from large-scale B cell receptor repertoire sequencing data.

Kaixuan Wang, Linru Cai, Hao Wang, Shiwen Shan, Xihao Hu, Jian Zhang

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kaixuan WangAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Linru CaiAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Hao WangAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China; Georgia Tech Shenzhen Institute (GTSI), Tianjin University, Shenzhen, Guangdong, China.
Shiwen ShanAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Xihao HuGV20 Therapeutics, Cambridge, MA, USA.
Jian ZhangAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China. Electronic address: jian_zhang@tju.edu.cn.
Tianjin University · CNG1 Therapeutics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expeditious identification and comprehensive analysis of clonal families from extensive B cell receptor (BCR) repertoire sequencing data are imperative for elucidating the intricacies of B cell immune responses. Here, we introduce a computational pipeline designed to swiftly deduce clonal families from bulk BCR heavy-chain sequencing data, accompanied by a suite of functional modules tailored to streamline post-clustering analysis. The outlined methodology encompasses guidelines for software installation, meticulous data preparation, and the systematic inference and analysis of clonal families. For complete details on the use and execution of this protocol, please refer to Wang et al.

Indexed as

Receptors, Antigen, B-CellSoftwareB-LymphocytesCluster AnalysisComputational BiologyHigh-Throughput Nucleotide SequencingHumansReceptors, Antigen, B-CellBioinformaticsImmunologySequence analysis

Identifiers

PMID38502687
PMCPMC10963638
OpenAlexW4392914877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.