Evidence map›Paper›PMID 38502472›Full record

ArticleClinical journal of gastroenterology2024

Safety and efficacy of atezolizumab plus bevacizumab combination therapy in patients with unresectable hepatocellular carcinoma undergoing dialysis: a case series.

Koki Sakaguchi, Tatsunori Satoh, Shinya Kawaguchi, Takuya Aoyama, Kazuhisa Asahara, Shinya Endo, Naofumi Shirane, Hideyuki Kanemoto, Noriyuki Oba, Kazuya Ohno

Abstract readCase Reports
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In one paragraph

Article in Clinical journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Koki SakaguchiDepartment of Gastroenterology, Shizuoka General Hospital, 4-27-1 Kita Ando, Aoi-Ku, Shizuoka City, Shizuoka, Japan.
Tatsunori SatohDepartment of Gastroenterology, Shizuoka General Hospital, 4-27-1 Kita Ando, Aoi-Ku, Shizuoka City, Shizuoka, Japan. tatsunori-sato@i.shizuoka-pho.jp.ORCID http://orcid.org/0000-0002-1756-3147
Shinya KawaguchiDepartment of Gastroenterology, Shizuoka General Hospital, 4-27-1 Kita Ando, Aoi-Ku, Shizuoka City, Shizuoka, Japan.
Takuya AoyamaDepartment of Gastroenterology, Yaizu City Hospital, Shizuoka, Japan.
Kazuhisa AsaharaDivision of Interventional Radiology, Shizuoka Cancer Center, Shizuoka, Japan.
Shinya EndoDepartment of Gastroenterology, Shizuoka General Hospital, 4-27-1 Kita Ando, Aoi-Ku, Shizuoka City, Shizuoka, Japan.
Naofumi ShiraneDepartment of Gastroenterology, Shizuoka General Hospital, 4-27-1 Kita Ando, Aoi-Ku, Shizuoka City, Shizuoka, Japan.
Hideyuki KanemotoDepartment of Gastroenterological Surgery, Shizuoka General Hospital, Shizuoka, Japan.
Noriyuki ObaDepartment of Gastroenterological Surgery, Shizuoka General Hospital, Shizuoka, Japan.
Kazuya OhnoDepartment of Gastroenterology, Shizuoka General Hospital, 4-27-1 Kita Ando, Aoi-Ku, Shizuoka City, Shizuoka, Japan.
Shizuoka General Hospital · JPShizuoka Cancer Center · JPShizuoka City Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three patients aged 79, 75, and 81 years with unresectable hepatocellular carcinoma (HCC) and undergoing maintenance hemodialysis were treated with a combination of atezolizumab and bevacizumab. The patients, respectively, received their 22nd, 2nd, and 4th treatment cycles, and one achieved long-term stable disease. No serious adverse events, including immune-related adverse events, were observed in any patient. Remarkable progress has been made in chemotherapy for cancer; however, the efficacy and safety of chemotherapy in patients undergoing hemodialysis have not been adequately elucidated. This report provides novel insights into the feasibility and outcomes of atezolizumab and bevacizumab combination therapy in patients with HCC undergoing hemodialysis, highlighting its potential as a viable treatment option with manageable side effects.

Indexed as

Antibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsBevacizumabCarcinoma, HepatocellularLiver NeoplasmsRenal DialysisAgedAged, 80 and overFemaleHumansMaleTreatment OutcomeAntibodies, Monoclonal, HumanizedatezolizumabBevacizumabChemotherapyHemodialysisHepatocellular carcinomaIrAE

Identifiers

PMID38502472
OpenAlexW4392950061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.