Evidence map›Paper›PMID 38502427›Full record

ArticleInfection2024

Canonical notch activation in patients with scrub typhus: association with organ dysfunction and poor outcome.

Jan K Damås, Kari Otterdal, Elisabeth Astrup, Tove Lekva, Jeshina Janardhanan, Annika Michelsen, Pål Aukrust, George M Varghese, Thor Ueland

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jan K DamåsDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Kari OtterdalResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Elisabeth AstrupResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Tove LekvaResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Jeshina JanardhananDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Annika MichelsenResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Pål AukrustResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
George M VargheseDepartment of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Thor UelandResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. thor.ueland@medisin.uio.no.
Oslo University Hospital · NOChristian Medical College · INChristian Medical College & Hospital · IN

Funding

Helse Sør-Øst RHF 2008046Norges Forskningsråd 196403
6 · The paper itself

Abstract

purposeThe mechanisms that control inflammation in scrub typhus are not fully elucidated. The Notch pathways are important regulators of inflammation and infection, but have not been investigated in scrub typhus.

methodsPlasma levels of the canonical Notch ligand Delta-like protein 1 (DLL1) were measured by enzyme immunoassay and RNA expression of the Notch receptors (NOTCH1, NOTCH2 and NOTCH4) in whole blood was analyzed by real-time PCR in patients with scrub typhus (n = 129), in patients with similar febrile illness without O. tsutsugamushi infection (n = 31) and in healthy controls (n = 31); all from the same area of South India.

resultsOur main results were: (i) plasma DLL1 was markedly increased in scrub typhus patients at hospital admission with a significant decrease during recovery. (ii) RNA expression of NOTCH4 was decreased at admission in whole blood. (iii) A similar pattern for DLL1 and NOTCH4 was seen in febrile disease controls. (iv) Admission DLL1 in plasma was associated with disease severity and short-term survival. (vi) Regulation of Notch pathways in O. tsutsugamushi-infected monocytes as evaluated by public repository data revealed enhanced canonical Notch activation with upregulation of DLL1 and downregulation of NOTCH4.

conclusionOur findings suggest that scrub typhus patients are characterized by enhanced canonical Notch activation. Elevated plasma levels of DLL1 were associated with organ dysfunction and poor outcomes in these patients.

Indexed as

Receptors, NotchScrub TyphusAdultAgedCalcium-Binding ProteinsFemaleHumansIndiaIntercellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiddle AgedMultiple Organ FailureOrientia tsutsugamushiYoung AdultCalcium-Binding ProteinsDLK1 protein, humanIntercellular Signaling Peptides and ProteinsMembrane ProteinsReceptors, NotchDelta-like 1InflammationNotch signalingOrientia tsutsugamushiScrub typhus

Identifiers

PMID38502427
PMCPMC11288987
OpenAlexW4392964597

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.