Evidence map›Paper›PMID 38502284›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2024

Insight into the role of copper-based materials against the coronaviruses MHV-3, a model for SARS-CoV-2, during the COVID-19 pandemic.

Gislaine S Jacinto, Leonardo F G Dias, Junko Tsukamoto, Paulo N Lisboa-Filho, Marina T Souza, Ana Paula de Moraes, Clarice W Arns

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Gislaine S JacintoLaboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, 13083-862, Brazil. g265711@dac.unicamp.br.
Leonardo F G DiasSorbonne Université, CNRS, Physicochimie des Électrolytes et Nanosystèmes InterfaciauX (PHENIX), 75005, Paris, France.
Junko TsukamotoLaboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, 13083-862, Brazil.
Paulo N Lisboa-FilhoDepartment of Physics and Meteorology, School of Sciences, UNESP - São Paulo State University, Bauru, São Paulo, 17033-360, Brazil.
Marina T SouzaCeRTEV - Center for Research, Technology and Education in Vitreous Materials, Vitreous Materials Laboratory, Department of Materials Engineering, Federal University of São Carlos, São Carlos, SP, Brazil.
Ana Paula de MoraesLaboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, 13083-862, Brazil.
Clarice W ArnsLaboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, 13083-862, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRCentre National de la Recherche Scientifique · FRUniversidade Estadual Paulista (Unesp) · BRUniversidade Federal de São Carlos · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior , Brasil 001
6 · The paper itself

Abstract

Coating high-touch surfaces with inorganic agents, such as metals, appears to be a promising long-term disinfection strategy. However, there is a lack of studies exploring the effectiveness of copper-based products against viruses. In this study, we evaluated the cytotoxicity and virucidal effectiveness of products and materials containing copper against mouse hepatitis virus (MHV-3), a surrogate model for SARS-CoV-2. The results demonstrate that pure CuO and Cu possess activity against the enveloped virus at very low concentrations, ranging from 0.001 to 0.1% (w/v). A greater virucidal efficacy of CuO was found for nanoparticles, which showed activity even against viruses that are more resistant to disinfection such as feline calicivirus (FCV). Most of the evaluated products, with concentrations of Cu or CuO between 0.003 and 15% (w/v), were effective against MHV-3. Cryomicroscopy images of an MHV-3 sample exposed to a CuO-containing surface showed extensive damage to the viral capsid, presumably due to the direct or indirect action of copper ions.

Indexed as

Antiviral AgentsCopperCOVID-19SARS-CoV-2AnimalsCatsHumansMiceMurine hepatitis virusPandemicsAntiviral AgentsCoppercupric oxideCopperMHV-3SARS-CoV-2Self-disinfectionVirucidal activity

Identifiers

PMID38502284
OpenAlexW4392954487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.