Evidence map›Paper›PMID 38502240›Full record

ArticleDiabetologia2024

No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts.

Nicolai A Lund-Blix, Anne A Bjerregaard, German Tapia, Ketil Størdal, Anne Lise Brantsæter, Marin Strøm, Thorhallur I Halldorsson, Charlotta Granstrøm, Jannet Svensson, Geir Joner and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 5 countries.

Nicolai A Lund-BlixNorwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-9092-7867
Anne A BjerregaardDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0628-5292
German TapiaNorwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-1770-1183
Ketil StørdalNorwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0001-7826-8646
Anne Lise BrantsæterNorwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0001-6315-7134
Marin StrømDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1926-6610
Thorhallur I HalldorssonDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5115-0162
Charlotta GranstrømDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Jannet SvenssonSteno Diabetes Center Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-9365-0728
Geir JonerFaculty of Medicine, Division of Paediatric and Adolescent Medicine, University of Oslo, Oslo, Norway.
Torild SkrivarhaugFaculty of Medicine, Division of Paediatric and Adolescent Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-4352-5929
Pål R NjølstadMohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-0304-6728
Sjurdur F OlsenDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3017-7096
Lars C SteneNorwegian Institute of Public Health, Oslo, Norway. lars.christian.stene@fhi.no.ORCID http://orcid.org/0000-0002-8434-119X
Statens Serum Institut · DKNorwegian Institute of Public Health · NOOslo University Hospital · NOHaukeland University Hospital · NOUniversity of Copenhagen · DK

Funding

European Union Horizon 2020 research and innovation programme 874864 HEDIMEDResearch Council of Norway 2210909/F20
6 · The paper itself

Abstract

aims/hypothesisThe aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children.

methodsThe Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis in children (n=634) was ascertained from national diabetes registries.

resultsThere was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes in offspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and the DNBC. Robustness analyses gave very similar results. CONCLUSIONS/

interpretationInitiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.

Indexed as

Diabetes Mellitus, Type 1Fatty Acids, Omega-3AdultChildCohort StudiesDenmarkDocosahexaenoic AcidsEicosapentaenoic AcidFemaleHumansMaleNorwayPregnancyPrenatal Exposure Delayed EffectsRisk FactorsDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Child healthCohort studiesHumanIntrauterine nutritionMaternal and child healthNutritionPregnancyType 1 diabetes

Identifiers

PMID38502240
PMCPMC11058590
OpenAlexW4392964380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.