Evidence map›Paper›PMID 38501912›Full record

ReviewChemistry (Weinheim an der Bergstrasse, Germany)2024

Genetically Fusing Order-Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials.

Sai S Patkar, Bin Wang, Ana Maria Mosquera, Kristi L Kiick

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Recombinant fibrous protein biomaterials meet skin tissue engineering.Frontiers in bioengineering and biotechnology · 2024
    Review
  3. Spontaneous Self-Organized Order Emerging From Intrinsically Disordered Protein Polymers.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sai S PatkarDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware, 19716, United States.ORCID https://orcid.org/0000-0002-7763-4031
Bin WangDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware, 19716, United States.
Ana Maria MosqueraDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware, 19716, United States.
Kristi L KiickDepartment of Materials Science and Engineering, University of Delaware, Newark, Delaware, 19716, United States.ORCID https://orcid.org/0000-0001-8587-0301

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
Understanding synovial macrophage inflamm-aging within osteoarthritisP20GM139760 · NIGMS · UNIVERSITY OF DELAWARE · PI DAWN M ELLIOTT · 2021 to 2026
$19.1M
UDE COBRE: STRAINED MOLECULES FOR SYNTHESIS OF UNNATURAL AMINO ACIDSP20RR017716 · NCRR · UNIVERSITY OF DELAWARE · PI BEEBE, THOMAS PAUL · 2002 to 2011
$16.9M
Highly resilient, hydrophilic bioelastomers for engineering vocal fold tissueR01DC011377 · NIDCD · UNIVERSITY OF DELAWARE · PI KIICK, KRISTI L · 2012 to 2016
$2.3M
Division of Materials Research 0239744Division of Materials Research 1609544Division of Materials Research 2004796Division of Materials Research 2004890Division of Materials Research 2011824NCRR NIH HHS P20 RR017716NIDCD NIH HHS R01 DC011377NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P20 GM139760NIH HHS DC011377NIH HHS GM103446NIH HHS GM139760NIH HHS P20GM104316NIH HHS P20 RR017716NSF NRT MIDAS 2125703
6 · The paper itself

Abstract

The unique biophysical and biochemical properties of intrinsically disordered proteins (IDPs) and their recombinant derivatives, intrinsically disordered protein polymers (IDPPs) offer opportunities for producing multistimuli-responsive materials; their sequence-encoded disorder and tendency for phase separation facilitate the development of multifunctional materials. This review highlights the strategies for enhancing the structural diversity of elastin-like polypeptides (ELPs) and resilin-like polypeptides (RLPs), and their self-assembled structures via genetic fusion to ordered motifs such as helical or beta sheet domains. In particular, this review describes approaches that harness the synergistic interplay between order-promoting and thermoresponsive building blocks to design hybrid biomaterials, resulting in well-structured, stimuli-responsive supramolecular materials ordered on the nanoscale.

Indexed as

Biocompatible MaterialsElastinPeptidesHumansInsect ProteinsIntrinsically Disordered ProteinsTemperatureBiocompatible MaterialsElastinInsect ProteinsIntrinsically Disordered ProteinsPeptidesresilindisordered proteinspeptidesphase transitionsself-assemblysupramolecular assembly

Identifiers

PMID38501912
PMCPMC11661552

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.