Evidence map›Paper›PMID 38501544›Full record

ArticleImmunity, inflammation and disease2024

Sodium butyrate activates the K

Ye Xu, Laofu Wen, Yunyi Tang, Zhenqiang Zhao, Miaojing Xu, Tan Wang, Zhibin Chen

Open access · goldAbstract read
In one paragraph

Article in Immunity, inflammation and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The α-synuclein proteostasis network and its translational applications in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Integrating causal human genetics andFrontiers in molecular biosciences · 2025
    Article
  11. Sodium butyrate activates the KImmunity, inflammation and disease · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ye XuDepartment of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Laofu WenDepartment of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Yunyi TangDepartment of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Zhenqiang ZhaoDepartment of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Miaojing XuDepartment of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.ORCID 0009-0009-5669-7680
Tan WangDepartment of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Zhibin ChenDepartment of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Hainan Medical University · CNNanfang Hospital · CN

Funding

Hainan Province Clinical Medical CenterHainan Provincial Natural Science Foundation of China 820QN399Hainan Provincial Natural Science Foundation of China 821RC1125Hainan Provincial Natural Science Foundation of China 822QN465
6 · The paper itself

Abstract

backgroundParkinson's disease (PD) is a common neurodegenerative disorder. Microglia-mediated neuroinflammation has emerged as an involving mechanism at the initiation and development of PD. Activation of adenosine triphosphate (ATP)-sensitive potassium (K

methodsWe established an in vitro PD model in BV2 cells using 1-methyl-4-phenylpyridinium (MPP

resultsNaB (5 mM) activated the K

conclusionNaB treatment alleviates the MPP

Indexed as

Parkinson Disease1-Methyl-4-phenylpyridiniumAnimalsAnti-Inflammatory AgentsButyric AcidCytokinesInflammationMicroglia1-Methyl-4-phenylpyridiniumAnti-Inflammatory AgentsButyric AcidCytokinesATP-sensitive potassium channelsmicroglianeuroinflammationParkinson's diseasesodium butyrate

Identifiers

PMID38501544
PMCPMC10949401
OpenAlexW4392956387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.