Evidence map›Paper›PMID 38501422›Full record

Trial reportNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Parecoxib sodium down-regulates CXCL8-CXCR1/2 to improve inflammatory microenvironment and promote patient recovery following laparoscopic radical resection of rectal cancer].

R Wu, R Liu, Y Zhang, X Li

Abstract readRandomized Controlled TrialEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

R WuDepartment of Anesthesiology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
R LiuDepartment of Anesthesiology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
Y ZhangDepartment of Anesthesiology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
X LiDepartment of Anesthesiology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China.
Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study the effect of parecoxib sodium on tumor microenvironment in patients undergoing laparoscopic radical resection of rectal cancer.

methodsSixty patients undergoing laparoscopic surgery for radical rectal cancer resection were randomized into test group and control group (

resultsCompared with the control patients, the patients in the test group showed significantly reduced plasma levels of IL-6, TNF-

conclusionParecoxib sodium can improve the inflammatory microenvironment to promote patient recovery after laparoscopic radical resection of rectal cancer possibly through a mechanism that down-regulates CXCL8-CXCR1/2 expressions in the PBMCs.

Indexed as

IsoxazolesLaparoscopyRectal NeoplasmsHumansInterleukin-6Leukocytes, MononuclearNeoplasm Recurrence, LocalPostoperative PainTumor MicroenvironmentTumor Necrosis Factor-alphaInterleukin-6IsoxazolesparecoxibTumor Necrosis Factor-alphachemokinesinflammationparecoxibperipheral blood mononuclear cellsrectal cancer

Identifiers

PMID38501422
PMCPMC10954531
OpenAlexW4394766290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.