Evidence map›Paper›PMID 38501415›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Adiponectin improves endometrial receptivity in rats with polycystic ovary syndrome by upregulating the PPARα/HOXA10 pathway].

J Wang, W Yang, J Liu, J Shi, P Xiao, M Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

J WangMicroscopic Morphology Experimental Center//The Institute of Clinical Anatomy and Reproductive Medicine// Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
W YangMicroscopic Morphology Experimental Center//The Institute of Clinical Anatomy and Reproductive Medicine// Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
J LiuMicroscopic Morphology Experimental Center//The Institute of Clinical Anatomy and Reproductive Medicine// Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
J ShiMicroscopic Morphology Experimental Center//The Institute of Clinical Anatomy and Reproductive Medicine// Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
P XiaoMicroscopic Morphology Experimental Center//The Institute of Clinical Anatomy and Reproductive Medicine// Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
M LiMicroscopic Morphology Experimental Center//The Institute of Clinical Anatomy and Reproductive Medicine// Department of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
University of South China · CNHunan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the role of the PPARα/HOXA10 signaling pathway in mediating the effect of adiponectin (APN) for improving endometrial receptivity in a rat model of polycystic ovary syndrome (PCOS).

methodsForty female SD rat models with letrozole-induced PCOS were randomized, with 10 normal rats as the control, into 4 equal groups for treatment with APN alone, APN combined with GW6471 (a specific PPARα inhibitor) or the vehicle for 20 days, or no further treatment (PCOS model group). GW6471 treatment (daily dose of 1 mg/kg) and vehicle treatment were initiated on the 11th day following the start of APN treatment, all administered via intraperitoneal injection. The rats were observed for changes in estrous cycle, body weight, ovarian index and morphology, uterine index and morphology, serum hormone levels and lipid metabolism parameters. Endometrial expressions of PPARα and HOXA10 were detected with immunohistochemistry and Western blotting. The development of endometrial pinopodes was observed under electron microscope, and pregnancies of the rats were recorded.

resultsThe rat models of PCOS exhibited obvious estrous cycle disorders with significantly prolonged estrous interval, increased body weight and ovarian index, decreased uterine index, disordered serum hormones and lipid metabolism (

conclusionAPN can improve endometrial receptivity in PCOS rats by upregulating the PARα/HOXA10 pathway.

Indexed as

Polycystic Ovary SyndromeAdiponectinAnimalsBody WeightFemaleHomeobox A10 ProteinsHumansPPAR alphaRatsRats, Sprague-DawleyAdiponectinHomeobox A10 ProteinsHOXA10 protein, humanPPAR alphaadiponectinendometrial receptivityHOXA10polycystic ovary syndromePPARα

Identifiers

PMID38501415
PMCPMC10954532
OpenAlexW4394760821

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.