Evidence map›Paper›PMID 38501414›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[High expression of COX6B2 in gastric cancer is associated with poor long-term prognosis and promotes cell proliferation and cell cycle progression by inhibiting p53 signaling].

M Shen, N Zhao, X Deng, M Deng

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

M ShenDepartment of Gastroenterology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
N ZhaoDepartment of Gastroenterology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
X DengDepartment of Gastroenterology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
M DengDepartment of Gastroenterology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of COX6B2 expression in gastric cancer tissues on the patients' long-term prognosis and its underlying mechanism.

methodsBased on the public databases and the medical records of patients, we analyzed the expression level of COX6B2 in gastric cancer and adjacent tissues and its influence on long-term prognosis of the patients. Enrichment analysis were used to predict the possible role of COX6B2 in gastric cancer. The effects of lentivirusmediated COX6B2 knockdown on biological behaviors of gastric cancer cells were examined using CCK-8 assay, flow cytometry, and Western blotting.

resultsTCGA database and the results of immunohistochemistry, Western blotting and realtime PCR all demonstrated a significantly higher expression of COX6B2 in gastric cancer tissues (

conclusions COX6B2 is highly expressed in gastric cancer and is closely correlated with a poor long-term prognosis of the patients possibly by promoting gastric cancer cell proliferation and regulating cell cycle.

Indexed as

Stomach NeoplasmsTumor Suppressor Protein p53CA-19-9 AntigenCell CycleCell Line, TumorCell ProliferationElectron Transport Complex IVGene Expression Regulation, NeoplasticHumansPrognosisCA-19-9 AntigenCOX6B1 protein, humanElectron Transport Complex IVTumor Suppressor Protein p53cell cyclecell proliferationCOX6B2gastric cancerlong-term prognosisp53

Identifiers

PMID38501414
PMCPMC10954525
OpenAlexW4394767549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.