Evidence map›Paper›PMID 38501339›Full record

ArticleThe Laryngoscope2024

Impact of Procedural Variation in Endoscopic Dilation for Idiopathic Subglottic Stenosis.

Pooja Santapuram, William S Tierney, Li-Ching Huang, Sheau-Chiann Chen, Lynn D Berry, David O Francis, Alexander Gelbard

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Guideline
  2. The use of centrifugated autologous lipoaspirate in the endoscopic management of idiopathic subglottic stenosis: results from a retrospective non-randomized study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Observational
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Pooja SantapuramDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, New York, U.S.A.ORCID 0000-0002-8284-9547
William S TierneyCleveland Clinic Voice Center, Cleveland, Ohio, U.S.A.
Li-Ching HuangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, U.S.A.
Sheau-Chiann ChenDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, U.S.A.
Lynn D BerryDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, U.S.A.
David O FrancisDepartment of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, U.S.A.
Alexander GelbardDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, U.S.A.ORCID 0000-0003-0078-1305
Vanderbilt University Medical Center · USCleveland Clinic · USColumbia University Irving Medical Center · USUniversity of Wisconsin–Madison · US

Funding

Molecular Interrogation of the Host-Pathogen Interface in Idiopathic Subglottic StensosisR01HL146401 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GELBARD, ALEXANDER · 2019 to 2023
$1.9M
Vanderbilt Training of Otolaryngology Physician Scientists (V-TOPS) ProgramR25DC020728 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Alexander Gelbard · 2023 to 2026
$729k
NHLBI NIH HHS R01 HL146401NHLBI NIH HHS R01HL146401NIDCD NIH HHS R25 DC020728
6 · The paper itself

Abstract

objectivesA small number of Idiopathic subglottic stenosis (iSGS) patients are treated at institutions across the country. Divergence in operative techniques for endoscopic dilation (ED) of iSGS has been anecdotally recognized but not formally characterized. Additionally, the relationship between procedural variation and clinical outcome has not been studied.

methodsSecondary analysis of the NoAAC iSGS

resultsThirteen NoAAC centers each enrolled >10 patients treated with ED for a total of 281 subjects. There was significant variation in procedural details and rate of recurrence among institutions. Hierarchal cluster analysis revealed significant heterogeneity among institutions and clusters in all procedural variables. However, analysis demonstrated a transient delay in disease recurrence in cluster 2 which disappeared with longer longitudinal follow-up. Patient-reported outcome and peak expiratory flow data supported the potential benefit of the technical variation in Cluster 2. Distinct to cluster 2, however, was routine use of adjuvant triple medical therapy (proton pump inhibitor (PPI), antibacterial agent, and steroid inhaler).

conclusionsBoth outcome and procedural technique vary among centers employing ED to treat iSGS. A transient delay in recurrence was observed among centers that routinely prescribed adjuvant medical therapy (antibiotic, inhaled corticosteroid, and PPI) to iSGS patients after endoscopic dilation, which was further supported by patient-reported data and peak expiratory flow data. Prospective studies are needed to understand the effects of adjuvant medical therapy on recurrence after endoscopic dilation. LEVEL OF EVIDENCE: 4 Laryngoscope, 134:3260-3266, 2024.

Indexed as

DilatationLaryngostenosisAdultAgedFemaleHumansLaryngoscopyMaleMiddle AgedRecurrenceTreatment Outcomecomparative techniquesendoscopic dilationidiopathic subglottic stenosis

Identifiers

PMID38501339
PMCPMC11493347
OpenAlexW4392959689

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.