ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Generalizability of EEG-Based DEMENTIA Classifiers: A Multicenter study of Alzheimer's, MCI, and FTD.medRxiv : the preprint server for health sciences · 2026Article
- Source-space EEG alpha activity reveals brain age gaps due to neurodegeneration and disparity.Communications biology · 2026Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.PLoS computational biology · 2026Article
- The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Creative experiences and brain clocks.Nature communications · 2025Article
- Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.Nature. Mental health · 2025Article
- Social exposome and brain health outcomes of dementia across Latin America.Nature communications · 2025Article
- A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition.bioRxiv : the preprint server for biology · 2025Article
- Digital twins and non-invasive recordings enable early diagnosis of Alzheimer's disease.Alzheimer's research & therapy · 2025Observational
- Electroencephalography (EEG) and the Quest for an Inclusive and Global Neuroscience.The European journal of neuroscience · 2025Article
- Brain neural mechanisms underlying VR enhanced aerobic exercise for mood enhancement in depressed adolescents.Frontiers in human neuroscience · 2025Article
- Homeodynamic feedback inhibition control in whole-brain simulations.PLoS computational biology · 2024Article
- Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations.Nature medicine · 2024Article
- Brain clocks capture diversity and disparity in aging and dementia.Research square · 2024Article
- Gaming expertise induces meso‑scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling.NeuroImage · 2024Article
- Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Virtual Brain links transcranial magnetic stimulation evoked potentials and inhibitory neurotransmitter changes in major depressive disorder.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
20 authors.
Funding
Abstract
introductionAlzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost-effective technique for studying dementia globally, but lacks mechanistic models and produces non-replicable results.
methodsWe developed a generative whole-brain model that combines EEG source-level metaconnectivity, anatomical priors, and a perturbational approach. This model was applied to Global South participants (AD, bvFTD, and healthy controls).
resultsMetaconnectivity outperformed pairwise connectivity and revealed more viscous dynamics in patients, with altered metaconnectivity patterns associated with multimodal disease presentation. The biophysical model showed that connectome disintegration and hypoexcitability triggered altered metaconnectivity dynamics and identified critical regions for brain stimulation. We replicated the main results in a second subset of participants for validation with unharmonized, heterogeneous recording settings. DISCUSSION: The results provide a novel agenda for developing mechanistic model-inspired characterization and therapies in clinical, translational, and computational neuroscience settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.