Evidence map›Paper›PMID 38501317›Full record

Trial reportAnnals of neurology2024

Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease.

Victor A Del Bene, Roy C Martin, Sarah A Brinkerhoff, Joseph W Olson, Matthew J Nelson, Dario Marotta, Christopher L Gonzalez, Kelly A Mills, Vidyulata Kamath, Gary Cutter and 7 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Effects of STN-DBS treatment on voice characteristics in patients with Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Victor A Del BeneDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0002-8562-5071
Roy C MartinDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Sarah A BrinkerhoffDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Joseph W OlsonDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Matthew J NelsonDepartment of Neurosurgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Dario MarottaDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Christopher L GonzalezDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Kelly A MillsDepartment of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Vidyulata KamathDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-7711-3597
Gary CutterSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Chris P HurtDepartment of Physical Therapy, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Melissa WadeDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Frank G RobinsonDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
J Nicole BentleyDepartment of Neurosurgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Barton L GuthrieDepartment of Neurosurgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Robert T KnightDepartment of Psychology, University of California, Berkeley, California, USA.
Harrison C WalkerDepartment of Neurology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USCivitan International · USJohns Hopkins University · USNeurosciences Institute · US

Funding

Noninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson's DiseaseUH3NS100553 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WALKER, HARRISON CARROLL · 2016 to 2021
$7.3M
Stimulus-evoked directional field potentials to guide subthalamic and pallidal DBS for PDUG3NS130202 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WALKER, HARRISON CARROLL · 2024 to 2024
$1.2M
Neurophysiological mechanisms of language comprehensionK01DC019165 · NIDCD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Matthew John Nelson · 2022 to 2026
$753k
NIDCD NIH HHS K01 DC019165NIH BRAIN Initiative 1UH3NS100553-01NINDS NIH HHS UG3 NS130202NINDS NIH HHS UH3 NS100553
6 · The paper itself

Abstract

objectiveThe aim of this study was to investigate the cognitive effects of unilateral directional versus ring subthalamic nucleus deep brain stimulation (STN DBS) in patients with advanced Parkinson's disease.

methodsWe examined 31 participants who underwent unilateral STN DBS (left n = 17; right n = 14) as part of an National Institutes of Health (NIH)-sponsored randomized, double-blind, crossover study contrasting directional versus ring stimulation. All participants received unilateral DBS implants in the hemisphere more severely affected by motor parkinsonism. Measures of cognition included verbal fluency, auditory-verbal memory, and response inhibition. We used mixed linear models to contrast the effects of directional versus ring stimulation and implant hemisphere on longitudinal cognitive function.

resultsCrossover analyses showed no evidence for group-level changes in cognitive performance related to directional versus ring stimulation. Implant hemisphere, however, impacted cognition in several ways. Left STN participants had lower baseline verbal fluency than patients with right implants (t [20.66 = -2.50, p = 0.02]). Verbal fluency declined after left (p = 0.013) but increased after right STN DBS (p < 0.001), and response inhibition was faster following right STN DBS (p = 0.031). Regardless of hemisphere, delayed recall declined modestly over time versus baseline (p = 0.001), and immediate recall was unchanged.

interpretationDirectional versus ring STN DBS did not differentially affect cognition. Similar to prior bilateral DBS studies, unilateral left stimulation worsened verbal fluency performance. In contrast, unilateral right STN surgery increased performance on verbal fluency and response inhibition tasks. Our findings raise the hypothesis that unilateral right STN DBS in selected patients with predominant right brain motor parkinsonism could mitigate declines in verbal fluency associated with the bilateral intervention. ANN NEUROL 2024;95:1205-1219.

Indexed as

CognitionCross-Over StudiesDeep Brain StimulationParkinson DiseaseSubthalamic NucleusAgedDouble-Blind MethodFemaleHumansMaleMiddle Aged

Identifiers

PMID38501317
PMCPMC11102318
OpenAlexW4392958452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.