Evidence map›Paper›PMID 38501293›Full record

ArticleBioscience reports2024

Prognostic and clinical significance of tumor-associated macrophages in esophageal squamous cell carcinoma after surgery: do biomarkers and distributions matter?

Bin Yi, Jun Zeng, Linfeng Li, Junjie Zhang, Yufan Chen, Yang Gao

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Article in Bioscience reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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5 · Who and what money

Authors and funding

6 authors.

Bin YiDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008 Hunan, P.R. China.
Jun ZengDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008 Hunan, P.R. China.
Linfeng LiDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008 Hunan, P.R. China.
Junjie ZhangDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008 Hunan, P.R. China.
Yufan ChenDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008 Hunan, P.R. China.
Yang GaoDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008 Hunan, P.R. China.ORCID 0000-0003-4834-7997

Funding

National Multidisciplinary Cooperative Diagnosis and Treatment Capacity Building Project for Major Diseases z027002The Project Program of National Clinical Research Center for Geriatric Disorders 2021LNJJ17
6 · The paper itself

Abstract

backgroundThe role of tumor-associated macrophages (TAMs) in patients with esophageal squamous cell carcinoma (ESCC) following surgery remains controversial. Hence, we performed the present study to systematically analyze the prognostic and clinical significance of distinct TAMs biomarkers and distributions in ESCC patients underwent surgery.

methodsPubMed, Web of Science, and EMBASE databases were searched up to March 31, 2023. The pooled analysis was conducted to evaluate the effects of TAMs on overall survival (OS), disease-free survival (DFS), and clinicopathological characteristics using fixed-effects or random-effect model.

resultsInvolving a total of 2,502 ESCC patients underwent surgery from 15 studies, the results suggested that the total count of CD68+ TAMs was inversely associated with OS and DFS in ESCC patients, which was also noticed in the relationship of CD68+ TAMs in tumor islet (TI) with OS (all P<0.05), although no association between CD68+ TAMs in tumor stroma (TS) and OS (P>0.05). Moreover, either islet or stromal CD163+ TAMs density was a prognostic factor ESCC (all P<0.05). Similarly, an elevated CD204+ TAMs density in TI predicted a poor DFS (P<0.05), although CD204+ TAMs in TI had no relationship with OS (P>0.05). Besides, a high CD68+ TAMs density was significantly associated with lymphatic vessel invasion, vascular invasion, and lymph node metastasis (all P<0.05).

conclusionOur results demonstrated the prognostic and clinical significance of TAMs in ESCC patients underwent surgery. TAMs should be considered a target that could improve prognostic stratification and clinical outcomes in ESCC after surgery.

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaBiomarkersBiomarkers, TumorClinical RelevanceHumansMacrophagesPrognosisTumor-Associated MacrophagesBiomarkersBiomarkers, TumorClinical significanceEsophageal squamous cell carcinomaPooled analysisPrognostic significanceTumor-associated macrophages

Identifiers

PMID38501293
PMCPMC10994813

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