Evidence map›Paper›PMID 38501173›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Biphasic regulation of miR-17∼92 transcription during hypoxia: roles of HIF1 and p53 hyperphosphorylation at ser15.

Miranda R Sun, Susana Gonzalez, Jason B Huang, Qiyuan Zhou, Arjun Cherukuri, Rohan Adavadkar, Hong-Li Yan, Shu-Han Sun, Guofei Zhou, J Usha Raj and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Miranda R SunDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, United States.
Susana GonzalezDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, United States.
Jason B HuangDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, United States.
Qiyuan ZhouDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, United States.
Arjun CherukuriDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, United States.
Rohan AdavadkarDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, United States.
Hong-Li YanDepartment of Medical Genetics, Second Military Medical University, Shanghai, People's Republic of China.ORCID 0000-0001-6366-0370
Shu-Han SunDepartment of Medical Genetics, Second Military Medical University, Shanghai, People's Republic of China.
Guofei ZhouDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, United States.
J Usha RajDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, United States.ORCID 0000-0002-7095-6820
Tianji ChenDepartment of Pediatrics, University of Illinois at Chicago, Chicago, Illinois, United States.ORCID 0000-0002-3026-2066
University of Illinois Chicago · USSecond Military Medical University · CNUniversity of Illinois System · US

Funding

Role of microRNA-17-92 and PDLIM5 Signaling in Pulmonary Arterial HypertensionR01HL123804 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RAJ, J. USHA, ZHOU, GUOFEI · 2015 to 2018
$1.6M
American Heart Association (AHA) 18CDA34110301Gilead Sciences (Gilead) NAHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL123804NHLBI NIH HHS R01 HL123804
6 · The paper itself

Abstract

We have reported previously that during hypoxia exposure, the expression of mature miR-17∼92 was first upregulated and then downregulated in pulmonary artery smooth muscle cells (PASMC) and in mouse lungs in vitro and in vivo. Here, we investigated the mechanisms regulating this biphasic expression of miR-17∼92 in PASMC in hypoxia. We measured the level of primary miR-17∼92 in PASMC during hypoxia exposure and found that short-term hypoxia exposure (3% O

Indexed as

E2F1 Transcription FactorHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsPulmonary ArteryTumor Suppressor Protein p53AnimalsCell HypoxiaCells, CulturedGene Expression RegulationHumansHypoxiaMiceMyocytes, Smooth MusclePhosphorylationPromoter Regions, GeneticSerineE2F1 Transcription FactorHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsSerineTumor Suppressor Protein p53biphasic regulationhypoxiamiR-17∼92PASMC

Identifiers

PMID38501173
PMCPMC11380943
OpenAlexW4392963204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.