Evidence map›Paper›PMID 38500996›Full record

ArticleHeliyon2024

Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant.

Gregory L Damhorst, Jessica Lin, Jennifer K Frediani, Julie A Sullivan, Adrianna Westbrook, Kaleb McLendon, Tyler J Baugh, William H O'Sick, John D Roback, Anne L Piantadosi and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Gregory L DamhorstAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Jessica LinAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Jennifer K FredianiAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Julie A SullivanAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Adrianna WestbrookAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Kaleb McLendonAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Tyler J BaughAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
William H O'SickAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
John D RobackAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Anne L PiantadosiAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Jesse J WaggonerAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Leda BassitAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Anuradha RaoAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Morgan GreenleafAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Jared W O'NealAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Seegar SwansonAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Nira R PollockAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Greg S MartinAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Wilbur A LamAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Joshua M LevyAtlanta Center for Microsystems-Engineered Point-of-Care Technologies, Emory University, USA.
Emory University · USGeorgia Institute of Technology · USBoston Children's Hospital · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Sinonasal and Olfaction ProgramZIADC000098 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI LEVY, JOSHUA · 2024 to 2025
$2.5M
NCATS NIH HHS UL1 TR002378
6 · The paper itself

Abstract

Limited data highlight the need to understand differences in SARS-CoV-2 omicron (B.1.1.529) variant viral load between the gold standard nasopharyngeal (NP) swab, mid-turbinate (MT)/anterior nasal swabs, oropharyngeal (OP) swabs, and saliva. MT, OP, and saliva samples from symptomatic individuals in Atlanta, GA, in January 2022 and longitudinal samples from a small familial cohort were tested by both RT-PCR and ultrasensitive antigen assays. Higher concentrations in the nares were observed in the familial cohort, but a dominant sample type was not found among 39 cases in the cross-sectional cohort. The composite of positive MT or OP assay for both RT-PCR and antigen assay trended toward higher diagnostic yield but did not achieve significant difference. Our data did not identify a singular preferred sample type for SARS-CoV-2 testing, but higher levels of saliva nucleocapsid, a trend toward higher yield of composite OP/MT result, and association of apparent MT or OP predominance with symptoms warrant further study.

Indexed as

COVID-19 testingPoint of care testingSARS-CoV-2SARS-CoV-2 variants

Identifiers

PMID38500996
PMCPMC10945130
OpenAlexW4392302801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.