Evidence map›Paper›PMID 38500966›Full record

ArticleNature cardiovascular research2023

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation.

Kyung Chan Park, Nicholas T Crump, Niamh Louwman, Steve Krywawych, Yuen Jian Cheong, Iolanda Vendrell, Eleanor K Gill, Mala Gunadasa-Rohling, Kerrie L Ford, David Hauton and 16 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 4 institutions in 1 country.

Kyung Chan ParkDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-7203-0127
Nicholas T CrumpMRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-9610-6763
Niamh LouwmanDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
Steve KrywawychDepartment of Chemical Pathology, Great Ormond Street Hospital NHS Foundation Trust, London, UK.
Yuen Jian CheongEpigenetics & Signalling Programmes, Babraham Institute, Cambridge, UK.ORCID https://orcid.org/0009-0008-9450-2576
Iolanda VendrellNuffield Department of Medicine, Target Discovery Institute, Oxford, UK.
Eleanor K GillDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
Mala Gunadasa-RohlingDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
Kerrie L FordDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
David HautonDepartment of Chemistry, University of Oxford, Oxford, UK.
Marjorie FournierDepartment of Biochemistry, University of Oxford, Oxford, UK.
Elisabete PiresDepartment of Chemistry, University of Oxford, Oxford, UK.
Lydia WatsonDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
Gerald RosemanDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
James HolderDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-7597-3104
Andreas KoschinskiDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0003-1876-3279
Ricardo CarnicerDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
M Kate CurtisDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-0096-8199
Manuela ZaccoloDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
Alzbeta HulikovaDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
Roman FischerNuffield Department of Medicine, Target Discovery Institute, Oxford, UK.ORCID https://orcid.org/0000-0002-9715-5951
Holger B KramerMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
James S O McCullaghDepartment of Chemistry, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0003-4733-1205
Sophie TrefelyEpigenetics & Signalling Programmes, Babraham Institute, Cambridge, UK.ORCID https://orcid.org/0000-0003-3816-6869
Thomas A MilneMRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-0413-4271
Pawel SwietachDepartment of Physiology, Anatomy & Genetics, University of Oxford, Oxford, UK.
University of Oxford · GBBabraham Institute · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBMRC Laboratory of Molecular Biology · GB

Funding

British Heart Foundation RG/15/9/31534British Heart Foundation RG/17/6/32944European Research Council 723997Medical Research Council MC_UU_00016/6Medical Research Council MC_UU_00029/6Medical Research Council MC_UU_12009/6
6 · The paper itself

Abstract

Propiogenic substrates and gut bacteria produce propionate, a post-translational protein modifier. In this study, we used a mouse model of propionic acidaemia (PA) to study how disturbances to propionate metabolism result in histone modifications and changes to gene expression that affect cardiac function. Plasma propionate surrogates were raised in PA mice, but female hearts manifested more profound changes in acyl-CoAs, histone propionylation and acetylation, and transcription. These resulted in moderate diastolic dysfunction with raised diastolic Ca

Identifiers

PMID38500966
PMCPMC7615744
OpenAlexW4388939425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.