Evidence map›Paper›PMID 38500836›Full record

ArticleiScience2024

The winged helix domain of MORF binds CpG islands and the TAZ2 domain of p300.

Dustin C Becht, Akinori Kanai, Soumi Biswas, Mohamed Halawa, Lei Zeng, Khan L Cox, Michael G Poirier, Ming-Ming Zhou, Xiaobing Shi, Akihiko Yokoyama and 1 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. A multivalent engagement of ENL with MOZ.Nature structural & molecular biology · 2025
    Article
  4. HBO1, a MYSTerious KAT and its links to cancer.Biochimica et biophysica acta. Gene regulatory mechanisms · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Dustin C BechtDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Akinori KanaiDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Kashiwa, Chiba 277-0882, Japan.
Soumi BiswasDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Mohamed HalawaDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Lei ZengBethune Institute of Epigenetic Medicine, First Hospital of Jilin University, Changchun 130061, China.
Khan L CoxDepartment of Physics, Ohio State University, Columbus, OH 43210, USA.
Michael G PoirierDepartment of Physics, Ohio State University, Columbus, OH 43210, USA.
Ming-Ming ZhouDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Xiaobing ShiDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Akihiko YokoyamaTsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Yamagata 997-0052, Japan.
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
University of Colorado Denver · USThe Ohio State University · USIcahn School of Medicine at Mount Sinai · USJilin University · CNNational Institute of Technology, Tsuruoka College · JPThe University of Tokyo · JPVan Andel Institute · US

Funding

Mechanisms of chromatin regulation of transcriptionR35GM139564 · NIGMS · OHIO STATE UNIVERSITY · PI POIRIER, MICHAEL GUY · 2021 to 2025
$3.6M
Targeting acetylated histone H4 by MLL4R01AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2021 to 2025
$2.1M
Transcriptional Mechanism of BRD4 in Solid TumorR01CA239165 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZHOU, MING-MING · 2019 to 2023
$2.0M
Molecular analysis of ASH1LR01CA252707 · NCI · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2020 to 2026
$1.9M
The role of JADE in HBO complexesR01HL151334 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.8M
Epigenetic mechanisms for regulation of p300R01GM135671 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.4M
Interdomain crosstalk in MORC3R01GM125195 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2017 to 2021
$1.3M
NCI NIH HHS R01 CA239165NCI NIH HHS R01 CA252707NHLBI NIH HHS R01 HL151334NIA NIH HHS R01 AG067664NIGMS NIH HHS R01 GM125195NIGMS NIH HHS R01 GM135671NIGMS NIH HHS R35 GM139564
6 · The paper itself

Abstract

Acetylation of histones by lysine acetyltransferases (KATs) provides a fundamental mechanism by which chromatin structure and transcriptional programs are regulated. Here, we describe a dual binding activity of the first winged helix domain of human MORF KAT (MORF

Indexed as

BiochemistryStructural biology

Identifiers

PMID38500836
PMCPMC10946326
OpenAlexW4392285994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.