Evidence map›Paper›PMID 38500818›Full record

ArticleiScience2024

HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling.

Emil Johansson, Jamirah Nazziwa, Eva Freyhult, Mun-Gwan Hong, Jacob Lindman, Malin Neptin, Sara Karlson, Melinda Rezeli, Antonio J Biague, Patrik Medstrand and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Emil JohanssonDepartment of Translational Medicine, Lund University, Lund, Sweden.
Jamirah NazziwaDepartment of Translational Medicine, Lund University, Lund, Sweden.
Eva FreyhultDepartment of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Mun-Gwan HongNational Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Jacob LindmanDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.
Malin NeptinDepartment of Translational Medicine, Lund University, Lund, Sweden.
Sara KarlsonLund University Virus Centre, Lund, Sweden.
Melinda RezeliBioMS - Swedish National Infrastructure for Biological Mass Spectrometry, Lund University, Lund, Sweden.
Antonio J BiagueNational Public Health Laboratory, Bissau, Guinea-Bissau.
Patrik MedstrandDepartment of Translational Medicine, Lund University, Lund, Sweden.
Fredrik MånssonDepartment of Translational Medicine, Lund University, Lund, Sweden.
Hans NorrgrenDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.
Joakim EsbjörnssonDepartment of Translational Medicine, Lund University, Lund, Sweden.
Marianne JanssonLund University Virus Centre, Lund, Sweden.
SWEGUB CORE group
Lund University · SENational Institute of Public Health · GWStockholm University · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-independent acquisition mass spectrometry to determine plasma signatures of tissue and cell type engagement. Proteins derived from target and bystander cells in multiple tissues, such as the gastrointestinal tract and brain, were detected at elevated levels in plasma of PLWH2, compared with HIV negative controls. Moreover, viremic HIV-2 infection appeared to induce enhanced release of proteins from a broader range of tissues compared to aviremic HIV-2 infection. This study expands the knowledge on the link between plasma proteome remodeling and the pathological cell engagement in tissues during HIV-2 infection.

Indexed as

DiseaseHuman specimenProteomicsVirology

Identifiers

PMID38500818
PMCPMC10945182
OpenAlexW4392245302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.