Evidence map›Paper›PMID 38500714›Full record

ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2024

The prevalence of gram-negative bacteria with difficult-to-treat resistance and utilization of novel β-lactam antibiotics in the southeastern United States.

Y Vivian Tsai, P Brandon Bookstaver, Joseph Kohn, Julie Ann Justo, Darrell Childress, Stefanie Stramel, Douglas Slain, Patrick Tu, Mary Joyce B Wingler, Bruce M Jones and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 1 country.

Y Vivian TsaiPrisma Health-Midlands, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-0551-4508
P Brandon BookstaverPrisma Health-Midlands, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-4409-0963
Joseph KohnPrisma Health-Midlands, Columbia, SC, USA.
Julie Ann JustoPrisma Health-Midlands, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-4161-9577
Darrell ChildressEast Alabama Medical Center, Opelika, AL, USA.ORCID https://orcid.org/0000-0002-8301-4023
Stefanie StramelDepartment of Pharmacy, Memorial Hermann Memorial City Medical Center, Houston, TX, USA.ORCID https://orcid.org/0000-0002-3811-982X
Douglas SlainDepartment of Clinical Pharmacy and Section of Infectious Diseases, West Virginia University, Morgantown, WV, USA.ORCID https://orcid.org/0000-0002-4318-7165
Patrick TuDepartment of Pharmacy, Charlie Norwood VA Medical Center, Augusta, GA, USA.ORCID https://orcid.org/0000-0003-4782-1538
Mary Joyce B WinglerDepartment of Antimicrobial Stewardship, University of Mississippi Medical Center, Jackson, MS, USA.ORCID https://orcid.org/0000-0002-2037-2616
Bruce M JonesSt. Joseph's/Candler Health System, Savannah, GA, USA.ORCID https://orcid.org/0000-0003-0461-2365
Daniel T AndersonDepartment of Pharmacy, Augusta University Medical Center, Augusta, GA, USA.
Megan M SeddonSarasota Memorial Health Care System, Sarasota, FL, USA.ORCID https://orcid.org/0009-0000-7851-3023
David A CretellaDepartment of Antimicrobial Stewardship, University of Mississippi Medical Center, Jackson, MS, USA.
Joshua EudyDepartment of Pharmacy, Augusta University Medical Center, Augusta, GA, USA.
Hana WindersPrisma Health-Midlands, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-6203-6522
Kayla AntoszDepartment of Clinical Pharmacy and Outcomes Sciences, University of South Carolina College of Pharmacy, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-0340-3409
Pamela BaileyPrisma Health-Midlands, Columbia, SC, USA.ORCID https://orcid.org/0000-0002-6953-8955
Majdi N Al-HasanPrisma Health-Midlands, Columbia, SC, USA.ORCID https://orcid.org/0000-0001-6501-492X
Prisma Health · USAugusta University Health · USUniversity of Mississippi Medical Center · USCharlie Norwood VA Medical Center · USMemorial Hermann Memorial City Medical Center · USSarasota Memorial Health Care System · USSt. Joseph’s Candler Hospital · USUniversity of South Alabama Medical Center · USUniversity of South Carolina · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate temporal trends in the prevalence of gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) in the southeastern United States. Secondary objective was to examine the use of novel β-lactams for GNB with DTR by both antimicrobial use (AU) and a novel metric of adjusted AU by microbiological burden (am-AU). Design: Retrospective, multicenter, cohort. Setting: Ten hospitals in the southeastern United States. Methods: GNB with DTR including Enterobacterales, Results: The overall prevalence of GNB with DTR was 0.85% (1,223/143,638) with numerical increase from 0.77% to 1.00% between 2015 and 2020 ( Conclusions: The overall prevalence of GNB with DTR and the use of novel β-lactams remain low. However, the uptrend in the use of novel β-lactams after adjusting for microbiological burden suggests a higher utilization relative to the prevalence of GNB with DTR.

Identifiers

PMID38500714
PMCPMC10945936
OpenAlexW4392919954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.