Automated Mapping of Residual Distortion Severity in Diffusion MRI.

Susceptibility-induced distortion is a common artifact in diffusion MRI (dMRI), which deforms the dMRI locally and poses significant challenges in connectivity analysis. While various methods were proposed to correct the distortion, residual distortions often persist at varying degrees across brain regions and subjects. Generating a voxel-level residual distortion severity map can thus be a valuable tool to better inform downstream connectivity analysis. To fill this current gap in dMRI analysis, we propose a supervised deep-learning network to predict a severity map of residual distortion. The training process is supervised using the structural similarity index measure (SSIM) of the fiber orientation distribution (FOD) in two opposite phase encoding (PE) directions. Only b0 images and related outputs from the distortion correction methods are needed as inputs in the testing process. The proposed method is applicable in large-scale datasets such as the UK Biobank, Adolescent Brain Cognitive Development (ABCD), and other emerging studies that only have complete dMRI data in one PE direction but acquires b0 images in both PEs. In our experiments, we trained the proposed model using the Lifespan Human Connectome Project Aging (HCP-Aging) dataset