Evidence map›Paper›PMID 38500536›Full record

ArticleAging biology2024

Early-Onset Hearing Loss in Mouse Models of Alzheimer's Disease and Increased DNA Damage in the Cochlea.

Jae-Hyeon Park, Burcin Duan Sahbaz, Komal Pekhale, Xixia Chu, Mustafa N Okur, Mhamed Grati, Kevin Isgrig, Wade Chien, Elena Chrysostomou, Lauren Sullivan and 3 more

Open access · goldAbstract read
In one paragraph

Article in Aging biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Roles of Sirtuins in Hearing Protection.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Jae-Hyeon ParkDNA repair Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Burcin Duan SahbazDNA repair Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Komal PekhaleDNA repair Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Xixia ChuDNA repair Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Mustafa N OkurDNA repair Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Mhamed GratiNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Kevin IsgrigNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Wade ChienNational Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Elena ChrysostomouWaitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA, USA.
Lauren SullivanDepartment of Cell & Developmental Biology School of Biological Sciences University of California, San Diego, La Jolla, CA, USA.
Deborah L CroteauDNA repair Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Uri ManorDepartment of Cell & Developmental Biology School of Biological Sciences University of California, San Diego, La Jolla, CA, USA.
Vilhelm A BohrDNA repair Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
National Institutes of Health · USInstitute on Aging · USNational Institute on Deafness and Other Communication Disorders · USSalk Institute for Biological Studies · USUniversity of California, San Diego · USUniversity of Copenhagen · DKUniversity of San Diego · US

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
Investigating the mechanisms of stereocilia length regulation and innovative strategies for restoring hearingR01DC021075 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Uri Manor · 2023 to 2026
$3.2M
Alzheimer's Disease Concept- OLFACTION AS AN EARLY BIOMARKER OF Alzheimer's DiseaseZIAAG000790 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2020 to 2022
$2.3M
Intramural NIH HHS ZIA AG000790NCI NIH HHS P30 CA014195NIA NIH HHS P30 AG068635NIDCD NIH HHS R01 DC021075
6 · The paper itself

Abstract

There is considerable interest in whether sensory deficiency is associated with the development of Alzheimer's disease (AD). Notably, the relationship between hearing impairment and AD is of high relevance but still poorly understood. In this study, we found early-onset hearing loss in two AD mouse models, 3xTgAD and 3xTgAD/Polβ

Identifiers

PMID38500536
PMCPMC10948084
OpenAlexW4392240411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.