Evidence map›Paper›PMID 38500529›Full record

ArticlePeerJ2024

Resting heart rate and risk of dementia: a Mendelian randomization study in the international genomics of Alzheimer's Project and UK Biobank.

Xingxing Chen, Yi Zheng, Jun Wang, Blake Yue, Xian Zhang, Kenta Nakai, Lijing L Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 5 countries.

Xingxing Chen *School of Public Health, Wuhan University, Wuhan, Hubei Province, China.
Yi Zheng *The University of Tokyo, Department of Computational Biology and Medical Science, Kashiwa, Japan.
Jun WangHuazhong University of Science and Technology, Department of Otorhinolaryngology of Union Hospital, Wuhan, Hubei Province, China.ORCID 0000-0002-4407-4445
Blake YueSchool of Business and Law, Edith Cowan University, Perth, WA, Australia.ORCID 0000-0002-6009-9714
Xian ZhangDuke Kunshan University, Global Health Research Center, Kunshan, Suzhou, China.ORCID 0009-0009-7803-5581
Kenta NakaiThe University of Tokyo, Department of Computational Biology and Medical Science, Kashiwa, Japan.
Lijing L YanSchool of Public Health, Wuhan University, Wuhan, Hubei Province, China.
The University of Tokyo · JPDuke Kunshan University · CNDuke University · USEdith Cowan University · AUWuhan Union Hospital · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Observational studies have demonstrated that a higher resting heart rate (RHR) is associated with an increased risk of dementia. However, it is not clear whether the association is causal. This study aimed to determine the causal effects of higher genetically predicted RHR on the risk of dementia. Methods: We performed a two-sample Mendelian randomization analysis to investigate the causal effect of higher genetically predicted RHR on Alzheimer's disease (AD) using summary statistics from genome-wide association studies. The generalized summary Mendelian randomization (GSMR) analysis was used to analyze the corresponding effects of RHR on following different outcomes: 1) diagnosis of AD (International Genomics of Alzheimer's Project), 2) family history (maternal and paternal) of AD from UK Biobank, 3) combined meta-analysis including these three GWAS results. Further analyses were conducted to determine the possibility of reverse causal association by adjusting for RHR modifying medication. Results: The results of GSMR showed no significant causal effect of higher genetically predicted RHR on the risk of AD (β Conclusion: Our study did not find any evidence that supports a causal effect of RHR on dementia. Previous observational associations between RHR and dementia are likely attributed to the correlation between RHR and other cardiovascular diseases.

Indexed as

Alzheimer DiseaseGenome-Wide Association StudyBiological Specimen BanksHeart RateHumansMendelian Randomization AnalysisMeta-Analysis as TopicUK BiobankAlzheimer’s diseaseDementiaGenetic variantsMendelian randomizationResting heart rate

Identifiers

PMID38500529
PMCPMC10946385
OpenAlexW4392872668

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.