Evidence map›Paper›PMID 38500494›Full record

ArticleJAACAP open2023

Structure of Psychopathology in Romanian Preschool-Aged Children in an Epidemiological and a High-Risk Sample.

Katherine L Guyon-Harris, André Plamondon, Kathryn L Humphreys, Mark Wade, Mary Margaret Gleason, Florin Tibu, Charles A Nelson, Nathan A Fox, Charles H Zeanah

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In one paragraph

Article in JAACAP open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00747396 (The Bucharest Early Intervention Project), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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NCT00747396 naactive not recruitingnot on this map

The Bucharest Early Intervention Project: Effects of Early Psychosocial Deprivation on Mental Health in Adolescence

TypeinterventionalSponsorCharles Alexander Nelson IIIRan2000 to 2027Enrolled136ConditionsCognitive Ability, General, Psychiatric and/or Mood Disorders, Brain Function, Social CognitionArmsFoster Care Placement
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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Katherine L Guyon-HarrisDr. Guyon-Harris is with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Drs. Plamondon and Wade are with the University of Toronto, Toronto, Ontario, Canada. Dr. Plamondon is also with Université Laval, Quebec, Canada. Drs. Humphreys, Gleason, and Zeanah are with Tulane University School of Medicine, New Orleans, Louisiana. Dr. Humphreys is also with Vanderbilt University, Nashville, Tennessee. Dr. Gleason is also with Eastern Virginia Medical School, Norfolk, Virginia. Dr. Tibu is with Stefan cel Mare University of Suceava, Suceava, Romania. Dr. Nelson is with Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, and Harvard Graduate School of Education, Boston, Massachusetts. Dr. Fox is with the University of Maryland, College Park, College Park, Maryland.ORCID 0000-0001-5990-6892
André PlamondonDr. Guyon-Harris is with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Drs. Plamondon and Wade are with the University of Toronto, Toronto, Ontario, Canada. Dr. Plamondon is also with Université Laval, Quebec, Canada. Drs. Humphreys, Gleason, and Zeanah are with Tulane University School of Medicine, New Orleans, Louisiana. Dr. Humphreys is also with Vanderbilt University, Nashville, Tennessee. Dr. Gleason is also with Eastern Virginia Medical School, Norfolk, Virginia. Dr. Tibu is with Stefan cel Mare University of Suceava, Suceava, Romania. Dr. Nelson is with Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, and Harvard Graduate School of Education, Boston, Massachusetts. Dr. Fox is with the University of Maryland, College Park, College Park, Maryland.ORCID 0000-0002-1169-2669
Kathryn L HumphreysDr. Guyon-Harris is with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Drs. Plamondon and Wade are with the University of Toronto, Toronto, Ontario, Canada. Dr. Plamondon is also with Université Laval, Quebec, Canada. Drs. Humphreys, Gleason, and Zeanah are with Tulane University School of Medicine, New Orleans, Louisiana. Dr. Humphreys is also with Vanderbilt University, Nashville, Tennessee. Dr. Gleason is also with Eastern Virginia Medical School, Norfolk, Virginia. Dr. Tibu is with Stefan cel Mare University of Suceava, Suceava, Romania. Dr. Nelson is with Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, and Harvard Graduate School of Education, Boston, Massachusetts. Dr. Fox is with the University of Maryland, College Park, College Park, Maryland.ORCID 0000-0002-5715-6597
Mark WadeDr. Guyon-Harris is with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Drs. Plamondon and Wade are with the University of Toronto, Toronto, Ontario, Canada. Dr. Plamondon is also with Université Laval, Quebec, Canada. Drs. Humphreys, Gleason, and Zeanah are with Tulane University School of Medicine, New Orleans, Louisiana. Dr. Humphreys is also with Vanderbilt University, Nashville, Tennessee. Dr. Gleason is also with Eastern Virginia Medical School, Norfolk, Virginia. Dr. Tibu is with Stefan cel Mare University of Suceava, Suceava, Romania. Dr. Nelson is with Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, and Harvard Graduate School of Education, Boston, Massachusetts. Dr. Fox is with the University of Maryland, College Park, College Park, Maryland.
Mary Margaret GleasonDr. Guyon-Harris is with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Drs. Plamondon and Wade are with the University of Toronto, Toronto, Ontario, Canada. Dr. Plamondon is also with Université Laval, Quebec, Canada. Drs. Humphreys, Gleason, and Zeanah are with Tulane University School of Medicine, New Orleans, Louisiana. Dr. Humphreys is also with Vanderbilt University, Nashville, Tennessee. Dr. Gleason is also with Eastern Virginia Medical School, Norfolk, Virginia. Dr. Tibu is with Stefan cel Mare University of Suceava, Suceava, Romania. Dr. Nelson is with Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, and Harvard Graduate School of Education, Boston, Massachusetts. Dr. Fox is with the University of Maryland, College Park, College Park, Maryland.ORCID 0000-0001-6843-9579
Florin TibuDr. Guyon-Harris is with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Drs. Plamondon and Wade are with the University of Toronto, Toronto, Ontario, Canada. Dr. Plamondon is also with Université Laval, Quebec, Canada. Drs. Humphreys, Gleason, and Zeanah are with Tulane University School of Medicine, New Orleans, Louisiana. Dr. Humphreys is also with Vanderbilt University, Nashville, Tennessee. Dr. Gleason is also with Eastern Virginia Medical School, Norfolk, Virginia. Dr. Tibu is with Stefan cel Mare University of Suceava, Suceava, Romania. Dr. Nelson is with Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, and Harvard Graduate School of Education, Boston, Massachusetts. Dr. Fox is with the University of Maryland, College Park, College Park, Maryland.ORCID 0000-0003-0873-1097
Charles A NelsonDr. Guyon-Harris is with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Drs. Plamondon and Wade are with the University of Toronto, Toronto, Ontario, Canada. Dr. Plamondon is also with Université Laval, Quebec, Canada. Drs. Humphreys, Gleason, and Zeanah are with Tulane University School of Medicine, New Orleans, Louisiana. Dr. Humphreys is also with Vanderbilt University, Nashville, Tennessee. Dr. Gleason is also with Eastern Virginia Medical School, Norfolk, Virginia. Dr. Tibu is with Stefan cel Mare University of Suceava, Suceava, Romania. Dr. Nelson is with Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, and Harvard Graduate School of Education, Boston, Massachusetts. Dr. Fox is with the University of Maryland, College Park, College Park, Maryland.ORCID 0000-0002-4723-247X
Nathan A FoxDr. Guyon-Harris is with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Drs. Plamondon and Wade are with the University of Toronto, Toronto, Ontario, Canada. Dr. Plamondon is also with Université Laval, Quebec, Canada. Drs. Humphreys, Gleason, and Zeanah are with Tulane University School of Medicine, New Orleans, Louisiana. Dr. Humphreys is also with Vanderbilt University, Nashville, Tennessee. Dr. Gleason is also with Eastern Virginia Medical School, Norfolk, Virginia. Dr. Tibu is with Stefan cel Mare University of Suceava, Suceava, Romania. Dr. Nelson is with Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, and Harvard Graduate School of Education, Boston, Massachusetts. Dr. Fox is with the University of Maryland, College Park, College Park, Maryland.
Charles H ZeanahDr. Guyon-Harris is with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Drs. Plamondon and Wade are with the University of Toronto, Toronto, Ontario, Canada. Dr. Plamondon is also with Université Laval, Quebec, Canada. Drs. Humphreys, Gleason, and Zeanah are with Tulane University School of Medicine, New Orleans, Louisiana. Dr. Humphreys is also with Vanderbilt University, Nashville, Tennessee. Dr. Gleason is also with Eastern Virginia Medical School, Norfolk, Virginia. Dr. Tibu is with Stefan cel Mare University of Suceava, Suceava, Romania. Dr. Nelson is with Boston Children's Hospital/Harvard Medical School, Boston, Massachusetts, and Harvard Graduate School of Education, Boston, Massachusetts. Dr. Fox is with the University of Maryland, College Park, College Park, Maryland.ORCID 0000-0002-7004-6819

Funding

The Relation Between Early Psychosocial Deprivation and Mental Health at 12 YearsR01MH091363 · NIMH · UNIV OF MARYLAND, COLLEGE PARK · PI FOX, NATHAN A, NELSON, CHARLES ALEXANDER · 2010 to 2024
$9.2M
Promoting positive parenting among pregnant women with opioid use disorderK23DA055092 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Katherine Guyon-Harris · 2022 to 2026
$767k
NIDA NIH HHS K23 DA055092NIMH NIH HHS R01 MH091363
6 · The paper itself

Abstract

Objective: Research on bifactor models of psychopathology in early childhood is limited to community samples with little longitudinal follow-up. We examined general and specific forms of psychopathology within 2 independent samples of preschool-aged Romanian children. Within a sample with children exposed to psychosocial deprivation, we also examined antecedents and longitudinal outcomes of the general factor. Method: One sample consisted of 350 Romanian children (mean age = 39.7 months, SD = 10.9) from an epidemiological study; the second sample consisted of 170 Romanian children (mean age = 55.6 months, SD = 1.9) exposed to severe early-life deprivation, as well as community comparison children, with longitudinal follow-up at 8 and 12 years. Psychopathology symptoms were assessed through caregiver-reported structured clinical interviews. Results: An SI-1 bifactor model of psychopathology was supported in both samples and included specific factors for externalizing, internalizing, and disturbed relatedness symptoms. In the second sample, longer duration of psychosocial deprivation and lower-quality caregiving were associated with higher scores on the general and all specific factors. Higher scores on the general factor were associated with later cognitive function, competence, and psychopathology symptoms. Considering all factors together, only the general factor explained variance in later childhood outcomes and was slightly stronger compared to a total symptom count for some, but not all, outcomes. Conclusion: General psychopathology in early childhood explains meaningful variance in child outcomes across multiple domains of functioning in later childhood. However, important questions remain regarding its clinical utility and usefulness, given complex measurement and limited explanatory power beyond the more accessible approach of a total symptom count. Clinical trial registration information: The Bucharest Early Intervention Project; https://clinicaltrials.gov/; NCT00747396.

Indexed as

bifactor modelinggeneral psychopathologypreschoolpsychosocial deprivation

Identifiers

PMID38500494
PMCPMC10947222

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