Evidence map›Paper›PMID 38500285›Full record

ArticleCurrent molecular medicine2025

CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model.

Zhongcheng Xie, Jimin Yang, Chunmeng Jiao, Hui Chen, Siyu Ouyang, Zhiyang Liu, Qin Hou, Jifeng Liu

Abstract read
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Article in Current molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Zhongcheng XieDepartment of Anatomy, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.ORCID 0000-0001-9070-9088
Jimin YangDepartment of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, 37 Guo Xue Lane, Chengdu 610064, Sichuan Province, China.ORCID 0000-0003-0484-6639
Chunmeng JiaoDepartment of Anatomy, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Hui ChenDepartment of Anatomy, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Siyu OuyangDepartment of Anatomy, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Zhiyang LiuDepartment of Anatomy, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Qin HouDepartment of Anatomy, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Jifeng LiuDepartment of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, 37 Guo Xue Lane, Chengdu 610064, Sichuan Province, China.
University of South China · CNSichuan University · CNFudan University · CNGuangdong Pharmaceutical University · CN

Funding

Foundation of Sichuan Provincial Science and Technology Program 2022JDR0091National Natural Science Foundation of China 82371883t1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University ZYJC21048
6 · The paper itself

Abstract

introductionSkeletal muscle degeneration is a common effect of chronic muscle injuries, including fibrosis and fatty infiltration, which is the replacement of preexisting parenchymal tissue by extracellular matrix proteins and abnormal invasive growth of fibroblasts and adipocytes.

methodThis remodeling limits muscle function and strength, eventually leading to reduced quality of life for those affected. Chemokines play a major role in the regulation of immunocyte migration, inflammation, and tissue remodeling and are implicated in various fibrotic and degenerative diseases. In this study, we aimed to investigate the role of the B-cell chemokine CXCL13 in the gastrocnemius muscle of the Achilles tendon rupture model mouse. We hypothesize that CXCL13 may promote fibrosis and aggravate skeletal muscle degeneration. We performed RNA sequencing and bioinformatics analysis of gastrocnemius muscle from normal and model mice to identify differentially expressed genes and signal pathways related to skeletal muscle degeneration and fibrosis.

resultsOur results show that CXCL13 is highly expressed in chronically degenerating skeletal muscle. Furthermore, CXCL13-neutralising antibodies with therapeutic potential were observed to inhibit fibrosis and adipogenesis

conclusionOur study reveals the underlying therapeutic implications of CXCL13 inhibition for clinical intervention in skeletal muscle degeneration, thereby improving patient prognosis.

Indexed as

Antibodies, NeutralizingChemokine CXCL13Muscle, SkeletalAdipogenesisAnimalsDisease Models, AnimalFibrosisMaleMiceMice, Inbred C57BLAntibodies, NeutralizingChemokine CXCL13Cxcl13 protein, mouseCXCL13fibroblastfibrosismuscle degenerationskeletal muscletissue.

Identifiers

PMID38500285
OpenAlexW4392965967

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.