Evidence map›Paper›PMID 38500230›Full record

ArticleJournal of animal science and biotechnology2024

Effects of the kinetic pattern of dietary glucose release on nitrogen utilization, the portal amino acid profile, and nutrient transporter expression in intestinal enterocytes in piglets.

Zexi Li, Yunfei Li, Yufei Zhao, Guifu Wang, Rujie Liu, Yue Li, Qamar Aftab, Zewei Sun, Qingzhen Zhong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  7. Big Data and AI-Powered Modeling: A Pathway to Sustainable Precision Animal Nutrition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zexi LiJilin Province Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, 2888 Xincheng Street, Changchun City, Jilin Province, People's Republic of China.
Yunfei LiJilin Province Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, 2888 Xincheng Street, Changchun City, Jilin Province, People's Republic of China.
Yufei ZhaoJilin Province Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, 2888 Xincheng Street, Changchun City, Jilin Province, People's Republic of China.
Guifu WangJilin Province Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, 2888 Xincheng Street, Changchun City, Jilin Province, People's Republic of China.
Rujie LiuJilin Province Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, 2888 Xincheng Street, Changchun City, Jilin Province, People's Republic of China.
Yue LiDongfeng County Sika Deer Industry Development Service Center, Dongfeng County, Liaoyuan City, Jilin Province, China.
Qamar AftabJilin Province Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, 2888 Xincheng Street, Changchun City, Jilin Province, People's Republic of China.
Zewei SunJilin Province Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, 2888 Xincheng Street, Changchun City, Jilin Province, People's Republic of China. sunzewei@jlau.edu.cn.ORCID http://orcid.org/0000-0003-3019-0741
Qingzhen ZhongJilin Province Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, 2888 Xincheng Street, Changchun City, Jilin Province, People's Republic of China. qingzhenzhong@163.com.
Jilin Agricultural University · CN

Funding

Jilin Province Key Research and Development Program of China 20220202044NCNational Key Research and Development Program of China 2021YFD1300201
6 · The paper itself

Abstract

backgroundPromoting the synchronization of glucose and amino acid release in the digestive tract of pigs could effectively improve dietary nitrogen utilization. The rational allocation of dietary starch sources and the exploration of appropriate dietary glucose release kinetics may promote the dynamic balance of dietary glucose and amino acid supplies. However, research on the effects of diets with different glucose release kinetic profiles on amino acid absorption and portal amino acid appearance in piglets is limited. This study aimed to investigate the effects of the kinetic pattern of dietary glucose release on nitrogen utilization, the portal amino acid profile, and nutrient transporter expression in intestinal enterocytes in piglets.

methodsSixty-four barrows (15.00 ± 1.12 kg) were randomly allotted to 4 groups and fed diets formulated with starch from corn, corn/barley, corn/sorghum, or corn/cassava combinations (diets were coded A, B, C, or D respectively). Protein retention, the concentrations of portal amino acid and glucose, and the relative expression of amino acid and glucose transporter mRNAs were investigated. In vitro digestion was used to compare the dietary glucose release profiles.

resultsFour piglet diets with different glucose release kinetics were constructed by adjusting starch sources. The in vivo appearance dynamics of portal glucose were consistent with those of in vitro dietary glucose release kinetics. Total nitrogen excretion was reduced in the piglets in group B, while apparent nitrogen digestibility and nitrogen retention increased (P < 0.05). Regardless of the time (2 h or 4 h after morning feeding), the portal total free amino acids content and contents of some individual amino acids (Thr, Glu, Gly, Ala, and Ile) of the piglets in group B were significantly higher than those in groups A, C, and D (P < 0.05). Cluster analysis showed that different glucose release kinetic patterns resulted in different portal amino acid patterns in piglets, which decreased gradually with the extension of feeding time. The portal His/Phe, Pro/Glu, Leu/Val, Lys/Met, Tyr/Ile and Ala/Gly appeared higher similarity among the diet treatments. In the anterior jejunum, the glucose transporter SGLT1 was significantly positively correlated with the amino acid transporters B

conclusionsRational allocation of starch resources could regulate dietary glucose release kinetics. In the present study, group B (corn/barley) diet exhibited a better glucose release kinetic pattern than the other groups, which could affect the portal amino acid contents and patterns by regulating the expression of amino acid transporters in the small intestine, thereby promoting nitrogen deposition in the body, and improving the utilization efficiency of dietary nitrogen.

Indexed as

Glucose release kineticsNitrogen utilizationNutrient transporterPiglet

Identifiers

PMID38500230
PMCPMC10946174
OpenAlexW4392923214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.