Evidence map›Paper›PMID 38500204›Full record

ArticleJournal of experimental & clinical cancer research : CR2024

Anaplastic thyroid cancer spheroids as preclinical models to test therapeutics.

Jiangnan Hu, Kaili Liu, Chandrayee Ghosh, Tejinder Pal Khaket, Helen Shih, Electron Kebebew

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. The Application of 3D Cell Culture in Thyroid Cancer.Annals of biomedical engineering · 2026
    Review
  2. Article
  3. Dual targeting of BRAFJournal of experimental & clinical cancer research : CR · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jiangnan HuDepartment of Surgery and Stanford Cancer Institute, Stanford University, Stanford, CA, USA. johu@stanford.edu.ORCID http://orcid.org/0000-0002-0112-7578
Kaili LiuStephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA.
Chandrayee GhoshDepartment of Surgery and Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Tejinder Pal KhaketDepartment of Surgery and Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Helen ShihDepartment of Surgery and Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Electron KebebewDepartment of Surgery and Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Stanford University · USUniversity of Oklahoma · US

Funding

Stanford Medicine Harry A. Oberhelman Jr. and Mark L. Welton Endowment Stanford Medicine Harry A. Oberhelman Jr. and Mark L. Welton Endowment
6 · The paper itself

Abstract

Anaplastic thyroid cancer (ATC) is the most aggressive thyroid cancer. Despite advances in tissue culture techniques, a robust model for ATC spheroid culture is yet to be developed. In this study, we created an efficient and cost-effective 3D tumor spheroids culture system from human ATC cells and existing cell lines that better mimic patient tumors and that can enhance our understanding of in vivo treatment response. We found that patient-derived ATC cells and cell lines can readily form spheroids in culture with a unique morphology, size, and cytoskeletal organization. We observed both cohesive (dense and solid structures) and discohesive (irregularly shaped structures) spheroids within the same culture condition across different cell lines. BRAF

Indexed as

Thyroid Carcinoma, AnaplasticThyroid NeoplasmsCell Line, TumorHumansProto-Oncogene Proteins B-rafProto-Oncogene Proteins B-rafAnaplastic thyroid cancerEpithelial–mesenchymal transitionGene expressionTreatment responseTumor spheroid

Identifiers

PMID38500204
PMCPMC10949686
OpenAlexW4392968224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.