Evidence map›Paper›PMID 38500055›Full record

ArticleBMC infectious diseases2024

Does HIV index testing bring patients into treatment at earlier stages of HIV disease? Results from a retrospective study in Ukraine.

Andrew M Secor, Alyona Ihnatiuk, Anna Shapoval, Misti McDowell, Larisa Hetman, Anjuli D Wagner, Jillian Pintye, Kristin Beima-Sofie, Matthew R Golden, Nancy Puttkammer

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Andrew M SecorDepartment of Global Health, University of Washington, Hans Rosling Center, 3980 15th Ave NE, 98105, Seattle, WA, USA. amsecor@gmail.com.
Alyona IhnatiukInternational Training and Education Center for Health (I-TECH), Kyiv, Ukraine.
Anna ShapovalInternational Training and Education Center for Health (I-TECH), Kyiv, Ukraine.
Misti McDowellInternational Training and Education Center for Health (I-TECH), Seattle, WA, USA.
Larisa HetmanPublic Health Center (PHC) of the Ministry of Health (MoH) of Ukraine, Kyiv, Ukraine.
Anjuli D WagnerDepartment of Global Health, University of Washington, Hans Rosling Center, 3980 15th Ave NE, 98105, Seattle, WA, USA.
Jillian PintyeDepartment of Global Health, University of Washington, Hans Rosling Center, 3980 15th Ave NE, 98105, Seattle, WA, USA.
Kristin Beima-SofieDepartment of Global Health, University of Washington, Hans Rosling Center, 3980 15th Ave NE, 98105, Seattle, WA, USA.
Matthew R GoldenDepartment of Medicine, University of Washington, Seattle, WA, USA.
Nancy PuttkammerDepartment of Global Health, University of Washington, Hans Rosling Center, 3980 15th Ave NE, 98105, Seattle, WA, USA.
University of Washington · USMinistry of Health · UAOffice of the National Coordinator for Health Information Technology · USPublic Health – Seattle & King County · US

Funding

HRSA HHS U91HA06801
6 · The paper itself

Abstract

backgroundOver one-third of people living with HIV (PLH) in Ukraine are not on treatment. Index testing services, which link potentially exposed partners (named partners) of known PLH (index patients) with testing and treatment services, are being scaled in Ukraine and could potentially close this gap.

methodsThis retrospective study included patient data from 14,554 adult PLH who initiated antiretroviral treatment (ART) between October 2018 and May 2021 at one of 35 facilities participating in an intervention to strengthen index testing services. Mixed effects modified Poisson models were used to assess differences between named partners and other ART initiators, and an interrupted time series (ITS) analysis was used to assess changes in ART initiation over time.

resultsCompared to other ART initiators, named partners were significantly less likely to have a confirmed TB diagnosis (aRR = 0.56, 95% CI = 0.40, 0.77, p < 0.001), a CD4 count less than 200 cells/mm

conclusionOur findings suggest that index testing services may be beneficial in bringing PLH into treatment at an earlier stage of HIV disease and decreasing delays between HIV testing and ART initiation, potentially improving patient outcomes and retention in the HIV care cascade.

Indexed as

Anti-HIV AgentsHIV InfectionsAdultAnti-Retroviral AgentsHIV TestingHumansRetrospective StudiesUkraineAnti-HIV AgentsAnti-Retroviral AgentsDifferentiated careHIV care continuumHIV testingIndex testing servicesLinkage to careUkraine

Identifiers

PMID38500055
PMCPMC10949801
OpenAlexW4392927658

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.