Evidence map›Paper›PMID 38500043›Full record

Trial reportBMC geriatrics2024

Effects of oral oligopeptide preparation and exercise intervention in older people with sarcopenia: a randomized controlled trial.

Xinyi Liao, Daomei Cheng, Jingjing Li, Lin Zhu, Suqiong Zhang, Xiaofan Jing, Lei Shi

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xinyi LiaoDepartment of Clinical Nutrition, West China Hospital, Sichuan University, Sichuan Province, Chengdu, China.
Daomei ChengSchool of Public Health, Chengdu Medical College, Sichuan Province, Chengdu, China.
Jingjing LiDepartment of Clinical Nutrition, West China Hospital, Sichuan University, Sichuan Province, Chengdu, China.
Lin ZhuZhengxing Community Health Service Center of Tianfu New District, Sichuan Province, Chengdu, China.
Suqiong ZhangShibantan Community Health Service Center of Xindu District, Sichuan Province, Chengdu, China.
Xiaofan JingDepartment of Clinical Nutrition, West China Hospital, Sichuan University, Sichuan Province, Chengdu, China. stephy1024@163.com.
Lei ShiDepartment of Clinical Nutrition, West China Hospital, Sichuan University, Sichuan Province, Chengdu, China. 271927115@qq.com.
West China Hospital of Sichuan University · CNChengdu Medical College · CN

Funding

Chinese Nutrition Society CNS-FF2019A23National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University Z20191013
6 · The paper itself

Abstract

backgroundNutrition and exercise are important interventions for sarcopenia. There were few studies on oral oligopeptide nutrition preparations combined with exercise to intervene in the older people with sarcopenia. The aim of this study was to verify the effectiveness of oligopeptide nutrition preparation combined with exercise intervention on the older people with sarcopenia in community.

methodsA total of 219 subjects aged 65 years or older with sarcopenia were randomly divided into 4 groups. The nutrition group (n = 58) was given individualized nutrition education and oral oligopeptide nutrition preparation. The exercise group (n = 50) received exercise intervention. The combined group (n = 52) received both oral nutrition preparation and exercise interventions. The control group (n = 59) only received individualized nutrition education. The nutrition preparation can provide energy 185kcal and protein 24.2g per day. The exercise intervention including warm-up exercise, resistance exercise and aerobic exercise, the training time was 60min for 5 times every week. The intervention lasted for 16 weeks. Hand grip strength, gait speed, body composition and hematology parameters were measured before and after intervention.

resultsA total of 159 subjects completed the study. Compared with baseline, the left grip strength and 6-m walking speed of the subjects in nutrition group increased significantly after the intervention, and the grip strength of both hands in exercise group and combined group increased significantly. The body weight of the subjects in nutrition group, exercise group and combined group increased significantly after intervention, but no increase in soft lean mass (SLM) and skeletal muscle mass (SMM) was observed in any of the four groups. The fat-free mass (FFM) of the legs of the control group, exercise group and nutrition group decreased after intervention, and only the FFM of the legs of the combined group maintained the level before the intervention.

conclusionBoth oral peptide nutrition and exercise interventions can improve the muscle strength or function of the older people with sarcopenia. However, there were no increases in muscle mass observed.

trial registrationChiCTR, ChiCTR2100052135. Registered 20 October 2021, https://www.chictr.org.cn/showproj.html?proj=135743.

Indexed as

Resistance TrainingSarcopeniaAgedExercise TherapyHand StrengthHumansMuscle, SkeletalMuscle StrengthOligopeptidesOligopeptidesNutritionOlder peoplePeptideSarcopenia

Identifiers

PMID38500043
PMCPMC10946144
OpenAlexW4392912103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.