Evidence map›Paper›PMID 38499959›Full record

ArticleGeroScience2024

RelA-mediated signaling connects adaptation to chronic cardiomyocyte stress with myocardial and systemic inflammation in the ADCY8 model of accelerated aging.

Vikas Kumar, Kevin Christian Bermea, Dhaneshwar Kumar, Amit Singh, Anjali Verma, Mary Kaileh, Ranjan Sen, Edward G Lakatta, Luigi Adamo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Vikas KumarLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA.
Kevin Christian BermeaDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Ross Research Building - Room 809, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Dhaneshwar KumarImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD, USA.
Amit SinghLaboratory of Molecular Biology & Immunology, Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Anjali VermaLaboratory of Clinical Investigation, Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Mary KailehLaboratory of Molecular Biology & Immunology, Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Ranjan SenLaboratory of Molecular Biology & Immunology, Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Edward G LakattaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD, 21224, USA. lakatta@grc.nia.nih.gov.
Luigi AdamoDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Ross Research Building - Room 809, 720 Rutland Avenue, Baltimore, MD, 21205, USA. ladamo2@jhmi.edu.ORCID 0000-0003-2704-978X
National Institutes of Health · USJohns Hopkins University · US

Funding

NF-kB activation and function in B lymphocytesZIAAG000376 · NIA · NATIONAL INSTITUTE ON AGING · PI SEN, RANJAN · 2009 to 2025
$5.9M
The TGAC8 Mouse, the mouse that roarsZIAAG000596 · NIA · NATIONAL INSTITUTE ON AGING · PI LAKATTA, EDWARD · 2019 to 2025
$2.6M
Myocardial-associated B lymphocytes and inflammatory injuryR01HL160716 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ADAMO, LUIGI · 2022 to 2025
$1.9M
Phenotype, dynamics and activation of myocardial B lymphocytes in response toischemia/reperfusion injuryK08HL145108 · NHLBI · WASHINGTON UNIVERSITY · PI ADAMO, LUIGI · 2019 to 2023
$753k
NHLBI Division of Intramural Research 1R01HL160716-01NHLBI Division of Intramural Research 5K08HLO145108-03NHLBI NIH HHS K08 HL145108NHLBI NIH HHS R01 HL160716
6 · The paper itself

Abstract

Mice with cardiac-specific overexpression of adenylyl cyclase (AC) type 8 (TG

Indexed as

Adenylyl CyclasesAgingInflammationMyocytes, CardiacSignal TransductionTranscription Factor RelAAdaptation, PhysiologicalAnimalsDisease Models, AnimalMiceMice, TransgenicMyocardiumadenylyl cyclase 8Adenylyl CyclasesRela protein, mouseTranscription Factor RelAAccelerated agingAdenylyl cyclase type 8Cardiac immunologyCardio-splenic axisInflammationNF-kB

Identifiers

PMID38499959
PMCPMC11335706
OpenAlexW4392964825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.