Evidence map›Paper›PMID 38499886›Full record

ArticleJournal of gastroenterology2024

Severe induction of aberrant DNA methylation by nodular gastritis in adults.

Akiko Sasaki, Hideyuki Takeshima, Satoshi Yamashita, Chikamasa Ichita, Jun Kawachi, Wataru Naito, Yui Ohashi, Chihiro Takeuchi, Masahide Fukuda, Yumi Furuichi and 9 more

Abstract read
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In one paragraph

Article in Journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Akiko SasakiDivision of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
Hideyuki TakeshimaDivision of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
Satoshi YamashitaDivision of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
Chikamasa IchitaGastroenterology Medicine Center, Shonan Kamakura General Hospital, Kanagawa, Japan.
Jun KawachiDepartment of General Surgery, Shonan Kamakura General Hospital, Kanagawa, Japan.
Wataru NaitoDepartment of Diagnostic Pathology, Shonan Kamakura General Hospital, Kanagawa, Japan.
Yui OhashiDepartment of Epigenomics, Institute for Advanced Life Sciences, Hoshi University, Tokyo, Japan.
Chihiro TakeuchiDivision of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
Masahide FukudaDivision of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
Yumi FuruichiDivision of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
Nobutake YamamichiCenter for Epidemiology and Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takayuki AndoThird Department of Internal Medicine, University of Toyama, Toyama, Japan.
Hideki KobaraDepartment of Gastroenterology and Neurology, Kagawa University, Kagawa, Japan.
Tohru KoteraDepartment of Medical Examination, Uji-Tokushukai Medical Center, Kyoto, Japan.
Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
Chihiro SumidaGastroenterology Medicine Center, Shonan Kamakura General Hospital, Kanagawa, Japan.
Akinobu HamadaDivision of Molecular Pharmacology, National Cancer Center Research Institute, Tokyo, Japan.
Kazuya KoizumiGastroenterology Medicine Center, Shonan Kamakura General Hospital, Kanagawa, Japan.
Toshikazu UshijimaDivision of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan. tushijima142@hoshi.ac.jp.ORCID 0000-0003-3405-7817
Shonan Kamakura General Hospital · JPHoshi University · JPKagawa University · JPOita University · JPThe University of Tokyo · JPTokyo Medical University · JPUniversity of Toyama · JP

Funding

Japan Agency for Medical Research and Development JP22ck0106552Japan Agency for Medical Research and Development JP22gm1310006Japan Society for the Promotion of Science JP21H03178Japan Society for the Promotion of Science JP21K07928Princess Takamatsu Cancer Research Fund 19-25138
6 · The paper itself

Abstract

backgroundNodular gastritis (NG) is characterized by marked antral lymphoid follicle formation, and is a strong risk factor for diffuse-type gastric cancer in adults. However, it is unknown whether aberrant DNA methylation, which is induced by atrophic gastritis (AG) and is a risk for gastric cancer, is induced by NG. Here, we analyzed methylation induction by NG.

methodsGastric mucosal samples were obtained from non-cancerous antral tissues of 16 NG and 20 AG patients with gastric cancer and 5 NG and 6 AG patients without, all age- and gender-matched. Genome-wide methylation analysis and expression analysis were conducted by a BeadChip array and RNA-sequencing, respectively.

resultsClustering analysis of non-cancerous antral tissues of NG and AG patients with gastric cancer was conducted using methylation levels of 585 promoter CpG islands (CGIs) of methylation-resistant genes, and a large fraction of NG samples formed a cluster with strong methylation induction. Promoter CGIs of CDH1 and DAPK1 tumor-suppressor genes were more methylated in NG than in AG. Notably, methylation levels of these genes were also higher in the antrum of NG patients without cancer. Genes related to lymphoid follicle formation, such as CXCL13/CXCR5 and CXCL12/CXCR4, had higher expression in NG, and genes involved in DNA demethylation TET2 and IDH1, had only half the expression in NG.

conclusionsSevere aberrant methylation, involving multiple tumor-suppressor genes, was induced in the gastric antrum and body of patients with NG, in accordance with their high gastric cancer risk.

Indexed as

CpG IslandsDNA MethylationGastric MucosaGastritis, AtrophicStomach NeoplasmsAdultAgedAntigens, CDCadherinsChemokine CXCL12Chemokine CXCL13DioxygenasesDNA-Binding ProteinsFemaleGastritisHumansAntigens, CDCadherinsCDH1 protein, humanChemokine CXCL12Chemokine CXCL13CXCL12 protein, humanCXCL13 protein, humanDioxygenasesDNA-Binding ProteinsProto-Oncogene ProteinsTET2 protein, humanChronic inflammationEpigeneticsHelicobacter pyloriMolecular epidemiology

Identifiers

PMID38499886
OpenAlexW4392965193

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.