Evidence map›Paper›PMID 38499825›Full record

Observational studyJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025

Cardioneuroablation for the management of patients with recurrent vasovagal syncope and symptomatic bradyarrhythmias: the CNA-FWRD Registry.

Tolga Aksu, Roderick Tung, Tom De Potter, Timothy M Markman, Pasquale Santangeli, Jeanne du Fay de Lavallaz, Jeffrey R Winterfield, Tina Baykaner, Daniel Alyesh, Jacqueline E Joza and 35 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Cardioneuroablation: A Comprehensive Review.Reviews in cardiovascular medicine · 2026
    Review
  3. Review
  4. Article
  5. Cardioneuroablation: the known and the unknown.Frontiers in cardiovascular medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors at 20 institutions in 8 countries.

Tolga AksuDepartment of Cardiology, Yeditepe University Hospital, 34100, Istanbul, Turkey.
Roderick TungThe University of Arizona College of Medicine, Banner-University Medical Center, 755 E McDowell Road, Phoenix, AZ, 85006, USA.
Tom De PotterDepartment of Cardiology, OLV Hospital, Aalst, Belgium.
Timothy M MarkmanDivision of Cardiology, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, USA.
Pasquale SantangeliSection of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Jeanne du Fay de LavallazDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Jeffrey R WinterfieldDivision of Cardiology, Medical University of South Carolina, Charleston, SC, USA.
Tina BaykanerDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Daniel AlyeshSouth Denver Cardiology Associates, 1000 SouthPark Drive, Littleton, CO, 80120, USA.
Jacqueline E JozaMcGill University, Montreal, QC, Canada.
Rakesh GopinathannairKansas City Heart Rhythm Institute, Overland Park, KS, USA.
Patrick BadertscherDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Duc H DoUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Ayman HusseinSection of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Jose OsorioArrhythmia Institute at Grandview, Birmingham, AL, USA.
Thomas DewlandElectrophysiology Section, Division of Cardiology, Department of Internal Medicine, University of California, San Francisco, San Francisco, CA, USA.
Alexander PerinoDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Albert J RodgersDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Christopher DeSimoneDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Alberto AlfieElectrophysiology Section, Cardiology Division, Hospital Nacional Profesor Alejandro Posadas, Av. Illia y Marconi S/N 1684, El Palomar, Moron, Province of Buenos Aires, Argentina.
Brett D AtwaterInova Heart and Vascular Institute, Falls Church, VA, USA.
David SinghThe Queens Medical Center, Honolulu, HI, USA.
Kapil KumarHarvard Medical School, Boston, MA, USA.
Jonathan SalcedoPalo Alto Medical Foundation-Sutter Health, Palo Alto, CA, USA.
Jason S BradfieldUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Gaurav UpadhyayCenter for Arrhythmia Care, Section of Cardiology, Pritzker School of Medicine, The University of Chicago Medicine, 5841 S. Maryland Avenue, MC 9024, Chicago, IL, 60637, USA.
Nitesh SoodArrhythmia Services, Southcoast Health, Fall River, MA, USA.
Parikshit S SharmaDepartment of Cardiology, Rush University Medical Center, Chicago, IL, USA.
Sandeep GautamDepartment of Cardiac Electrophysiology, University of Missouri-Columbia, Columbia, MO, USA.
Vineet KumarInova Heart and Vascular Institute, Falls Church, VA, USA.
Alexander Romeno Janner Dal FornoServiço de Arritmia e Marcapasso - Hospital SOS Cardio - Florianópolis, Florianópolis, SC, Brazil.
Christopher E WoodsDepartment of Cardiology, California Pacific Medical Center, San Francisco, CA, USA.
Moshe Rav-AchaJesselson Integrated Heart Center, Shaare Zedek Hospital, 9112102, Jerusalem, Israel.
Chiara ValerianoDepartment of Cardiology, OLV Hospital, Aalst, Belgium.
Sunil KapurCardiac Arrhythmia Service, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Andres EnriquezDivision of Cardiology, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, USA.
Sri SundaramSouth Denver Cardiology Associates, 1000 SouthPark Drive, Littleton, CO, 80120, USA.
Michael GliksonJesselson Integrated Heart Center, Shaare Zedek Hospital, 9112102, Jerusalem, Israel.
Edward GerstenfeldElectrophysiology Section, Division of Cardiology, Department of Internal Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jonathan PicciniDuke Clinical Research Institute, Duke University Hospital, Durham, USA.
Wendy S TzouDivision of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
William SauerCardiac Arrhythmia Service, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Andre d'AvilaHarvard Medical School, Boston, MA, USA.
Kalyanam ShivkumarUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Henry D HuangDepartment of Cardiology, Rush University Medical Center, Chicago, IL, USA. Henry_d_huang@rush.edu.
Stanford University · USUniversity of California, Los Angeles · USAlaska Heart and Vascular Institute · USBrigham and Women's Hospital · USCapital Cardiology Associates · USCleveland Clinic · USHarvard University · USHospital of the University of Pennsylvania · USOnze Lieve Vrouwziekenhuis Hospital · BERush University Medical Center · USShaare Zedek Medical Center · ILUniversity Hospital of Basel · CHUniversity of California, San Francisco · USCalifornia Pacific Medical Center · USDuke University Hospital · USFundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina · BRHeart Rhythm Society · USHospital Posadas · ARMayo Clinic in Arizona · USMcGill University · CA

Funding

Deep Neural Networks To Treat Atrial FibrillationK23HL145017 · NHLBI · STANFORD UNIVERSITY · PI BAYKANER, TINA · 2019 to 2023
$968k
NHLBI NIH HHS K23 HL145017
6 · The paper itself

Abstract

backgroundCardioneuroablation has been emerging as a potential treatment alternative in appropriately selected patients with cardioinhibitory vasovagal syncope (VVS) and functional AV block (AVB). However the majority of available evidence has been derived from retrospective cohort studies performed by experienced operators.

methodsThe Cardioneuroablation for the Management of Patients with Recurrent Vasovagal Syncope and Symptomatic Bradyarrhythmias (CNA-FWRD) Registry is a multicenter prospective registry with cross-over design evaluating acute and long-term outcomes of VVS and AVB patients treated by conservative therapy and CNA.

resultsThe study is a prospective observational registry with cross-over design for analysis of outcomes between a control group (i.e., behavioral and medical therapy only) and intervention group (Cardioneuroablation). Primary and secondary outcomes will only be assessed after enrollment in the registry. The follow-up period will be 3 years after enrollment.

conclusionsThere remains a lack of prospective multicentered data for long-term outcomes comparing conservative therapy to radiofrequency CNA procedures particularly for key outcomes including recurrence of syncope, AV block, durable impact of disruption of the autonomic nervous system, and long-term complications after CNA. The CNA-FWRD registry has the potential to help fill this information gap.

Indexed as

BradycardiaCatheter AblationRegistriesSyncope, VasovagalAdultCross-Over StudiesFemaleHumansMaleMiddle AgedProspective StudiesRecurrenceTreatment OutcomeAV blockCardioneuroablationGanglionated plexiSyncopeVasovagal syncope

Identifiers

PMID38499825
PMCPMC12064083
OpenAlexW4392906031

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.