Evidence map›Paper›PMID 38499769›Full record

ReviewNature reviews. Genetics2024

Dynamics of ER stress-induced gene regulation in plants.

Dae Kwan Ko, Federica Brandizzi

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dae Kwan KoMSU-DOE Plant Research Lab, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-9720-5138
Federica BrandizziMSU-DOE Plant Research Lab, Michigan State University, East Lansing, MI, USA. fb@msu.edu.ORCID 0000-0003-0580-8888

Funding

Unfolded protein response in the model species Arabidopsis thalianaR35GM136637 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Federica Brandizzi · 2020 to 2026
$2.6M
NIGMS NIH HHS R35 GM136637
6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress is a potentially lethal condition that is induced by the abnormal accumulation of unfolded or misfolded secretory proteins in the ER. In eukaryotes, ER stress is managed by the unfolded protein response (UPR) through a tightly regulated, yet highly dynamic, reprogramming of gene transcription. Although the core principles of the UPR are similar across eukaryotes, unique features of the plant UPR reflect the adaptability of plants to their ever-changing environments and the need to balance the demands of growth and development with the response to environmental stressors. The past decades have seen notable progress in understanding the mechanisms underlying ER stress sensing and signalling transduction pathways, implicating the UPR in the effects of physiological and induced ER stress on plant growth and crop yield. Facilitated by sequencing technologies and advances in genetic and genomic resources, recent efforts have driven the discovery of transcriptional regulators and elucidated the mechanisms that mediate the dynamic and precise gene regulation in response to ER stress at the systems level.

Indexed as

Endoplasmic Reticulum StressGene Expression Regulation, PlantPlantsUnfolded Protein ResponseEndoplasmic ReticulumSignal Transduction

Identifiers

PMID38499769
PMCPMC11186725

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.