ArticleNature biomedical engineering2024
Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation.
Article in Nature biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
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Who cites it
18 citing papers in PubMed.
- Applications of synthetic biology in biomedicine.Molecular biomedicine · 2026Review
- Mechanically-activated electrochemical implantable micro-supercapacitors boosting wound healing in the small intestine.Nature communications · 2026Article
- Electronics-free soft robotic minitablet for on-demand gastric molecular sensing and diagnostics in vivo.Science advances · 2026Article
- Transforming healthcare through in-body bioelectronic systems.Nature communications · 2026Review
- Autofluorescence-free ratiometric temperature monitoring with multiple emissive persistent luminescent nanothermometers.Analytical and bioanalytical chemistry · 2026Article
- Flexible Polymer-Based Electronics for Human Health Monitoring: A Safety-Level-Oriented Review of Materials and Applications.Nano-micro letters · 2026Review
- Superelastic Tellurium Thermoelectric Coatings for Advanced Trimodal Microsensing.Nature communications · 2026Article
- Biodegradable Implantable Electronics with Wireless Technology for Real-Time Clinical Applications.Advanced healthcare materials · 2026Review
- 4D printing of trigger-free shape-memory hydrogels towards self-adaptive substrates for bioelectronics.Nature communications · 2025Article
- Submucosal electronics for long-term in situ diagnosis and therapeutics of gastrointestinal diseases.Nature reviews. Gastroenterology & hepatology · 2025Article
- A Deep-Learned Monolithic Nanoparticle Asymmetric Thermal Flow Sensor for Flow Vector Estimation.ACS nano · 2025Article
- Accessing the viscera: Technologies for interoception research.Current opinion in neurobiology · 2025Review
- Recent Advances in Stimuli-Responsive Materials and Soft Robotic Actuators for Bioelectronic Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Implantable bioelectronics and wearable sensors for kidney health and disease.Nature reviews. Nephrology · 2025Review
- Monitoring Mouse Surface Temperature During Stress with a Thermal Camera: A Low-Cost Infrared Videography System for Evaluating Murine Metabolism.Current protocols · 2025Article
- Article
- Inflammatory Bowel Disease: A Comprehensive Analysis of Molecular Bases, Predictive Biomarkers, Diagnostic Methods, and Therapeutic Options.International journal of molecular sciences · 2024Review
- One-Dimensional Implantable Sensors for Accurately Monitoring Physiological and Biochemical Signals.Research (Washington, D.C.) · 2024Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Diagnosing and monitoring inflammatory bowel diseases, such as Crohn's disease, involves the use of endoscopic imaging, biopsies and serology. These infrequent tests cannot, however, identify sudden onsets and severe flare-ups to facilitate early intervention. Hence, about 70% of patients with Crohn's disease require surgical intestinal resections in their lifetime. Here we report wireless, miniaturized and implantable temperature sensors for the real-time chronic monitoring of disease progression, which we tested for nearly 4 months in a mouse model of Crohn's-disease-like ileitis. Local measurements of intestinal temperature via intraperitoneally implanted sensors held in place against abdominal muscular tissue via two sutures showed the development of ultradian rhythms at approximately 5 weeks before the visual emergence of inflammatory skip lesions. The ultradian rhythms showed correlations with variations in the concentrations of stress hormones and inflammatory cytokines in blood. Decreasing average temperatures over the span of approximately 23 weeks were accompanied by an increasing percentage of inflammatory species in ileal lesions. These miniaturized temperature sensors may aid the early treatment of inflammatory bowel diseases upon the detection of episodic flare-ups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.