Evidence map›Paper›PMID 38498680›Full record

ArticleAstrobiology2024

Stability of 20 Biogenic Amino Acids in Concentrated Sulfuric Acid: Implications for the Habitability of Venus' Clouds.

Maxwell D Seager, Sara Seager, William Bains, Janusz J Petkowski

Open access · greenAbstract read
In one paragraph

Article in Astrobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 citations in OpenAlex.

  1. Peptides adopt stable omega-loop structures in concentrated sulfuric acid.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
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  4. Article
  5. Article
  6. Warm, water-depleted rocky exoplanets with surface ionic liquids: A proposed class for planetary habitability.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. The diversity of exoplanetary environments and the search for signs of life beyond Earth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  8. Life on Venus?Life (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Maxwell D SeagerDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
Sara SeagerNanoplanet Consulting, Concord, Massachusetts, USA.ORCID 0000-0002-6892-6948
William BainsDepartment of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Janusz J PetkowskiDepartment of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-1921-4848
Massachusetts Institute of Technology · USCardiff University · GBWorcester Polytechnic Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scientists have long speculated about the potential habitability of Venus, not at the 700K surface, but in the cloud layers located at 48-60 km altitudes, where temperatures match those found on Earth's surface. However, the prevailing belief has been that Venus' clouds cannot support life due to the cloud chemical composition of concentrated sulfuric acid-a highly aggressive solvent. In this work, we study 20 biogenic amino acids at the range of Venus' cloud sulfuric acid concentrations (81% and 98% w/w, the rest water) and temperatures. We find 19 of the biogenic amino acids we tested are either unreactive (13 in 98% w/w and 12 in 81% w/w) or chemically modified in the side chain only, after 4 weeks. Our major finding, therefore, is that the amino acid backbone remains intact in concentrated sulfuric acid. These findings significantly broaden the range of biologically relevant molecules that could be components of a biochemistry based on a concentrated sulfuric acid solvent.

Indexed as

VenusAmino AcidsAtmosphereSolventsSulfuric AcidsAmino AcidsSolventsSulfuric AcidsAmino acidsHabitabilityNMRSulfuric acidVenus

Identifiers

PMID38498680
PMCPMC11035925
OpenAlexW4390601168

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.