Evidence map›Paper›PMID 38498238›Full record

ArticleMolecular biology reports2024

Valproate modulates the activity of multidrug resistance efflux pumps, as a chemoresistance factor in gastric cancer cells.

Sayedeh Azimeh Hosseini, Seyed Abbas Mirzaei, Shahriar Kermani, Hajar Yaghoobi

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sayedeh Azimeh HosseiniStudent Research Commitee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Seyed Abbas MirzaeiDepartment of Medical Biotechnology, School of Advanced Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Shahriar KermaniStudent Research Commitee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Hajar YaghoobiClinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. hajar.yaghoobi64@gmail.com.
Shahrekord University of Medical Sciences · IR

Funding

Shahrekord University of Medical Sciences SKUMS-3703
6 · The paper itself

Abstract

backgroundDrug resistance is one of the most critical problems in gastric cancer therapy. This study was performed to investigate the valproic acid effects on the proliferation of sensitive and resistant cell lines of human gastric cancer, and to explore the mechanism of the agent on multi drug resistance and apoptosis genes.

methodsThe cytotoxicity effect of valproic acid on the EPG85.257 and EPG85.257RDB cells was assessed by the MTT assay, and the IC

resultsDose-dependent toxicity was recorded after treatment of cells with valproic acid. Valproic acid represented a significant growth inhibition on EPG85.257 cells with IC

conclusionsValproate can affect drug resistance in gastric cancer via a unique mechanism independent of MDR1 expression.

Indexed as

Stomach NeoplasmsApoptosisAutophagy-Related ProteinsCell Line, TumorDrug Resistance, MultipleDrug Resistance, NeoplasmHumansTumor Suppressor Protein p53Valproic AcidVesicular Transport ProteinsAutophagy-Related ProteinsEPG5 protein, humanTumor Suppressor Protein p53Valproic AcidVesicular Transport ProteinsApoptosisDrug resistanceGastric cancerMDR1Valproic acid

Identifiers

PMID38498238
OpenAlexW4392926317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.