Evidence map›Paper›PMID 38498197›Full record

ArticleJournal of bone and mineral metabolism2024

Associations of pyrethroid exposure with bone mineral density and osteopenia in adults.

Zhubin Shen, Fengyi Zhang, Xiaoqing Guan, Zhiming Liu, Yuan Zong, Ding Zhang, Rui Wang, Qian Xue, Wenxuan Ma, Ruijian Zhuge and 2 more

Abstract read
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In one paragraph

Article in Journal of bone and mineral metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zhubin ShenDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, China. shenzb21@mails.jlu.edu.cn.
Fengyi ZhangDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, China.
Xiaoqing GuanDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, China.
Zhiming LiuDepartment of Spine Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Yuan ZongDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, China.
Ding ZhangDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, China.
Rui WangDepartment of Toxicology, School of Public, Health of Jilin University, Changchun, 130021, China.
Qian XueDepartment of Toxicology, School of Public, Health of Jilin University, Changchun, 130021, China.
Wenxuan MaDepartment of Toxicology, School of Public, Health of Jilin University, Changchun, 130021, China.
Ruijian ZhugeDepartment of Toxicology, School of Public, Health of Jilin University, Changchun, 130021, China.
Li GuoDepartment of Toxicology, School of Public, Health of Jilin University, Changchun, 130021, China.
Fei YinDepartment of Spine Surgery, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun, 130033, China. yinfei999@jlu.edu.cn.
Jilin University · CNUnion Hospital · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study was to investigate the correlations between pyrethroid exposure and bone mineral density (BMD) and osteopenia. MATERIALS AND

methodsThis cross-sectional study included 1389 participants over 50 years of age drawn from the 2007-2010 and 2013-2014 National Health and Nutrition Examination Survey (NHANES). Three pyrethroid metabolites, 3-phenoxybenzoic acid (3-PBA), trans-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropane-1-carboxylic acid (trans-DCCA), and 4-fluoro-3-phenoxybenzoic acid (4-F-3PBA) were used as indicators of pyrethroid exposure. Low BMD was defined as T-score < - 1.0, including osteopenia. Weighted multivariable linear regression analysis or logistic regression analysis was utilized to evaluate the correlation between pyrethroid exposure and BMD and low BMD. Bayesian kernel machine regression (BKMR) model was utilized to analyze the correlation between pyrethroids mixed exposure and low BMD.

resultsThere were 648 (48.41%) patients with low BMD. In individual pyrethroid metabolite analysis, both tertile 2 and tertile 3 of trans-DCCA were negatively related to total femur, femur neck, and total spine BMD [coefficient (β) = - 0.041 to - 0.028; all P < 0.05]. Both tertile 2 and tertile 3 of 4-F-3PBA were negatively related to total femur BMD (P < 0.05). Only tertile 2 [odds ratio (OR) = 1.63; 95% CI = 1.07, 2.48] and tertile 3 (OR = 1.65; 95% CI = 1.10, 2.50) of trans-DCCA was correlated with an increased risk of low BMD. The BKMR analysis indicated that there was a positive tendency between mixed pyrethroids exposure and low BMD.

conclusionIn conclusion, pyrethroids exposure was negatively correlated with BMD levels, and the associations of pyrethroids with BMD and low BMD varied by specific pyrethroids, pyrethroid concentrations, and bone sites.

Indexed as

BenzoatesBone Diseases, MetabolicInsecticidesPhenyl EthersPyrethrinsAdultBayes TheoremBone DensityCross-Sectional StudiesEnvironmental ExposureHumansMiddle AgedNutrition Surveys3-phenoxybenzoic acid4-carboxybiphenyl etherBenzoatesInsecticidesPhenyl EthersPyrethrinsBone mineral densityEndocrine disruptor chemicalsOsteopeniaPyrethroids

Identifiers

PMID38498197
OpenAlexW4392917934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.