When deep learning is not enough: artificial life as a supplementary tool for segmentation of ultrasound images of breast cancer.

Segmentation of tumors in ultrasound (US) images of the breast is a critical issue in medical imaging. Due to the poor quality of US images and the varying specifications of US machines, segmentation and classification of abnormalities present difficulties even for trained radiologists. The paper aims to introduce a novel AI-based hybrid model for US segmentation that offers high accuracy, requires relatively smaller datasets, and is capable of handling previously unseen data. The software can be used for diagnostics and the US-guided biopsies. A unique and robust hybrid approach that combines deep learning (DL) and multi-agent artificial life (AL) has been introduced. The algorithms are verified on three US datasets. The method outperforms 14 selected state-of-the-art algorithms applied to US images characterized by complex geometry and high level of noise. The paper offers an original classification of the images and tests to analyze the limits of the DL. The model has been trained and verified on 1264 ultrasound images. The images are in the JPEG and PNG formats. The age of the patients ranges from 22 to 73 years. The 14 benchmark algorithms include deformable shapes, edge linking, superpixels, machine learning, and DL methods. The tests use eight-region shape- and contour-based evaluation metrics. The proposed method (DL-AL) produces excellent results in terms of the dice coefficient (region) and the relative Hausdorff distance H