Evidence map›Paper›PMID 38498100›Full record

ReviewPurinergic signalling2024

Cutaneous melanoma and purinergic modulation by phenolic compounds.

Geórgia de Carvalho Braga, João Victor Coiado, Vitória Capelli de Melo, Brenno Bianchoni Loureiro, Margarete Dulce Bagatini

Open access · greenAbstract readReview
In one paragraph

Review in Purinergic signalling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. AC3Medical oncology (Northwood, London, England) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Geórgia de Carvalho BragaMedical School, Federal University of Fronteira Sul, Chapecó, SC, Brazil.ORCID http://orcid.org/0000-0003-0384-9934
João Victor CoiadoMedical School, Federal University of Fronteira Sul, Chapecó, SC, Brazil.ORCID http://orcid.org/0000-0003-1770-4736
Vitória Capelli de MeloMedical School, Federal University of Fronteira Sul, Chapecó, SC, Brazil.ORCID http://orcid.org/0000-0002-4286-5083
Brenno Bianchoni LoureiroMedical School, Federal University of Fronteira Sul, Chapecó, SC, Brazil.ORCID http://orcid.org/0009-0006-8557-248X
Margarete Dulce BagatiniGraduate Program in Medical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil. margaretebagatini@yahoo.com.br.ORCID http://orcid.org/0000-0001-9263-4980
Universidade Federal da Fronteira Sul · BR

Funding

from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 404256/2021-0 and 310606/2021-7Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina 2021TR1543
6 · The paper itself

Abstract

Cutaneous melanoma is a complex pathology that still has only treatments that lack efficiency and offer many adverse effects. Due to this scenario emerges the need to analyze other possible treatments against this disease, such as the effect of phenolic compounds. These substances have proven antitumor effects, but still have not been fully explored as a form of therapy to combat melanoma. Also, the purinergic receptors, along with its system molecules, take part in the formation of tumors from many pathways, such as the actions of ectoenzymes and receptors activity, especially P2Rs family, and are formed by structures that can be modulated by the phenolic compounds. Therefore, more studies have to be made with the aim of explaining the purinergic system activity in carcinogenesis of cutaneous melanoma and the effects of its modulation by phenolic compound, in order to enable the development of new therapies to combat this aggressive and feared cancer.

Indexed as

MelanomaPhenolsReceptors, PurinergicSkin NeoplasmsAnimalsCutaneous Malignant MelanomaHumansPhenolsReceptors, PurinergicMelanomaModulationPhenolicPurinergic

Identifiers

PMID38498100
PMCPMC11555167
OpenAlexW4392916584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.