Evidence map›Paper›PMID 38498066›Full record

Observational studyJapanese journal of ophthalmology2024

Aging-associated changes of optical coherence tomography-measured ganglion cell-related retinal layer thickness and visual sensitivity in normal Japanese.

Aiko Iwase, Tomomi Higashide, Makoto Fujii, Yuko Ohno, Yuki Tanaka, Tsutomu Kikawa, Makoto Araie

Abstract readObservational Study
In one paragraph

Observational study in Japanese journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Longitudinal hemifield-specific macular ganglion cell complex thinning and its association with arterial stiffness in eyes without baseline glaucomatous abnormalities.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aiko IwaseTajimi Iwase Eye Clinic, 3-101-1, Honmachi, Tajimi, Gifu Prefecture, 507-0033, Japan. aiko-gif@umin.net.ORCID http://orcid.org/0000-0001-5950-4260
Tomomi HigashideDepartment of Ophthalmology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Makoto FujiiDivision of Health and Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
Yuko OhnoDivision of Health and Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
Yuki TanakaSanten Pharmaceutical, Tokyo, Japan.
Tsutomu KikawaTopcon Corporation, Tokyo, Japan.
Makoto AraieKanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report aging-associated change rates in circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular ganglion cell-inner plexiform layer and complex thickness (MGCIPLT, MGCCT) in normal Japanese eyes and to compare the data in linear scaled visual field (VF) sensitivity of central 4 points of Humphrey Field Analyzer (HFA) 24-2 test (VF STUDY

designProspective observational study

methodsHFA 24-2 tests and spectral-domain optical coherence tomography (SD-OCT) measurements of cpRNFLT, MGCIPLT, MGCCT and GCIPLT

resultsThe aging-associated change rates were -0.064 μm/year for MGCIPLT and and -0.095 for MGCCT (P=0.020 and 0.017), but could not be detected for cpRNFLT. They accelerated with aging at -0.009μm/year/year of age for MGCIPLT (P<0.001), at 0.011 for MGCCT (P<0.001) and at 0.013 for cpRNFLT(0.031). The aging-associated decline of -82.1 [1/Lambert]/year of VF

conclusionWe report that aging-associated change rates of cpRNFLT, MGCIPLT and MGCCT in normal Japanese eyes were found to be significantly accelerated along with aging. Relationship between VF sensitivity decline rates and SD-OCT measured GCIPLT decline rates during physiological aging in the corresponding parafoveal retinal areas are also documented.

Indexed as

RetinaTomography, Optical CoherenceAgingHumansJapanMiddle AgedRetinal Ganglion CellsVisual Field TestsAging-associated decline rateCircumpapillary retinal nerve fiber layer thicknesMacular ganglion-cell complex thicknessMacular ganglion cell-inner plexiform layer thicknessNormal healthy eyes

Identifiers

PMID38498066
PMCPMC10963440

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.