Evidence map›Paper›PMID 38497931›Full record

SynthesisHepatology communications2024

Racial and ethnic disparities in alcohol-associated liver disease in the United States: A systematic review and meta-analysis.

Ahmad Anouti, Karim Seif El Dahan, Nicole E Rich, Jeremy Louissaint, William M Lee, Sarah R Lieber, Juan Pablo Arab, Bill Y Zhang, Mausam J Patel, Chanattha Thimphittaya and 8 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Hepatology communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Current Clinical Trials for Alcohol-Associated Hepatitis.The American journal of pathology · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Ahmad AnoutiDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.
Karim Seif El DahanDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0003-4268-4079
Nicole E RichDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0003-2740-8818
Jeremy LouissaintDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0003-1154-1825
William M LeeDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.
Sarah R LieberDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-8304-4479
Juan Pablo ArabDepartment of Medicine, Division of Gastroenterology, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada.ORCID 0000-0002-8561-396
Bill Y ZhangUniversity of Texas Southwestern Medical School, Dallas, Texas, USA.
Mausam J PatelDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Chanattha ThimphittayaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Luis Antonio DíazDepartamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0002-8540-4930
Dyanna L GregoryDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.
Julia KozlitinaDepartment of Internal Medicine, The Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern, Dallas, Texas, USA.
Lisa B VanWagnerDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-6264-2573
Andrea C KingDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Comprehensive Cancer Center, Chicago, Illinois, USA.
Mack C MitchellDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.
Amit G SingalDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-1172-3971
Thomas G CotterDepartment of Internal Medicine, Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-0376-0107
Southwestern Medical CenterThe University of Texas Southwestern Medical Center · USPontificia Universidad Católica de Chile · CLUniversity of Chicago · USWestern University · CA

Funding

A Multi-Center Study of Acute Liver Failure in AdultsU01DK058369 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DURKALSKI, VALERIE L, FONTANA, ROBERT J · 2005 to 2019
$27.4M
Alcohol Stimulation and Sedation in Binge Drinkers - Renewal 01R01AA013746 · NIAAA · UNIVERSITY OF CHICAGO · PI DANIEL J FRIDBERG, ANDREA C KING · 2003 to 2026
$11.6M
Multilevel factors for racial/ethnic and socioeconomic disparities in prognosis of hepatocellular carcinomaR01MD012565 · NIMHD · UT SOUTHWESTERN MEDICAL CENTER · PI SINGAL, AMIT, YOPP, ADAM · 2018 to 2022
$4.3M
Multi-level Evaluation of Racial/ethnic Disparities in Liver Disease OutcomesR01CA256977 · NCI · BAYLOR COLLEGE OF MEDICINE · PI KANWAL, FASIHA, SINGAL, AMIT · 2021 to 2025
$3.0M
Integrated therapies for alcohol use and ALD (ITAALD) Network – UTSW Clinical CenterU01AA026975 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI E SHERWOOD BROWN, Mack Clarence Mitchell · 2018 to 2026
$3.0M
E-cigarette use as a smoking cueR01DA044210 · NIDA · UNIVERSITY OF CHICAGO · PI KING, ANDREA C · 2018 to 2021
$2.1M
Blood pressure as a modifiable risk factor for cardiovascular events in liver transplant recipientsR56HL155093 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI VANWAGNER, LISA B · 2021 to 2021
$774k
Determining the Influence of Clinicodemographic, Biologic and SDOH Factors in Racial and Ethnic Disparities in the Prognosis of Alcohol-Associated Liver DiseaseK23AA031310 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI COTTER, THOMAS GERARD · 2023 to 2025
$580k
Natural environment assessment of alcohol responses in risky drinkersR21AA029746 · NIAAA · UNIVERSITY OF CHICAGO · PI FRIDBERG, DANIEL J, KING, ANDREA C · 2022 to 2023
$446k
NCI NIH HHS R01 CA256977NHLBI NIH HHS R56 HL155093NIAAA NIH HHS K23 AA031310NIAAA NIH HHS R01 AA013746NIAAA NIH HHS R21 AA029746NIAAA NIH HHS U01 AA026975NIDA NIH HHS R01 DA044210NIDDK NIH HHS U01 DK058369NIMHD NIH HHS R01 MD012565
6 · The paper itself

Abstract

backgroundAlcohol-associated liver disease (ALD), encompassing alcohol-associated hepatitis and alcohol-associated cirrhosis, is rising in the United States. Racial and ethnic disparities are evident within ALD; however, the precise nature of these disparities is poorly defined.

methodsWe conducted a search of the PubMed/MEDLINE and EMBASE databases to identify studies published from inception through September 2023 that reported ALD incidence, prevalence, and mortality within the United States, stratified by race and ethnicity. We calculated pooled prevalence and incidence by race and ethnicity, including risk ratios and ORs for ALD pooled prevalence and alcohol-associated hepatitis/alcohol-associated cirrhosis pooled proportions, and OR for ALD mortality using the DerSimonian and Laird method for random-effect models.

resultsWe identified 25 relevant studies (16 for quantitative meta-analysis), comprising 76,867,544 patients. ALD prevalence was highest in Hispanic (4.5%), followed by White (3.1%) and Black (1.4%) individuals. Pooled risk ratios of ALD prevalence were 1.64 (95% CI: 1.12-2.39) for Hispanic and 0.59 (95% CI: 0.35-0.87) for Black compared to White individuals. Mortality among those with ALD did not significantly differ between White and Hispanic (OR: 1.54, 95% CI: 0.9-2.5; I2=0%), Black (OR: 1.2, 95% CI: 0.8-1.6; I2=0%), or Native American (OR: 2.41, 95% CI: 0.9-2.9) individuals, while there was a significant difference between White and Asian (OR: 0.1; 95% CI: 0.03-0.5) individuals. Most data were cross-sectional and assessed to be of poor or fair quality.

conclusionsDifferences were observed in ALD epidemiology, including higher prevalence among Hispanic and lower prevalence among Black individuals, although there were smaller differences in ALD mortality. Differences in ALD prevalence and prognosis remain poorly defined based on existing data, highlighting a need for higher-quality epidemiological studies in this area.

Indexed as

Hepatitis, AlcoholicLiver Diseases, AlcoholicEthnicityHealth Status DisparitiesHumansLiver CirrhosisLiver Cirrhosis, AlcoholicRacial GroupsUnited States

Identifiers

PMID38497931
PMCPMC10948135
OpenAlexW4392927812

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.