ArticleThe Journal of experimental medicine2024
Competitive fungal commensalism mitigates candidiasis pathology.
Article in The Journal of experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Kefir-derived probiotic mixture for children with autism spectrum disorder: a double-blind randomized clinical trial.BMC pediatrics · 2026Trial
- A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.iScience · 2026Article
- Commensal fungus to the rescue of gut injury.Nature microbiology · 2026Article
- A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection.bioRxiv : the preprint server for biology · 2026Article
- CUMS alters behavioral phenotypes and gut mycobiota in mice.Frontiers in microbiology · 2026Article
- Sterol-C4-methyl-oxidase Erg251 governs Candida albicans hypoxic growth, commensalism and virulence.Nature communications · 2025Article
- The human mycobiome: a critical yet understudied component of health and disease.Microbiology (Reading, England) · 2025Review
- Microbiota-mediated mechanisms of mucosal immunity across the lifespan.Nature immunology · 2025Review
- Gut fungi are associated with human genetic variation and disease risk.PLoS biology · 2025Article
- Commensalism and pathogenesis of Candida albicans at the mucosal interface.Nature reviews. Microbiology · 2025Review
- Variations in oral health outcomes and mycobiome composition among COVID-19 convalescents.Scientific reports · 2025Article
- Fungal pathogen-responsive Th17 cells in gut-mouth axis enhance protection against oropharyngeal candidiasis.iScience · 2025Article
- Composition, Influencing Factors, and Effects on Host Nutrient Metabolism of Fungi in Gastrointestinal Tract of Monogastric Animals.Animals : an open access journal from MDPI · 2025Review
- Article
- One in, one out: Commensal fungus protects against infection.The Journal of experimental medicine · 2024Article
- Draft genome ofMicrobiology resource announcements · 2024Article
Corrections and comments
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Authors and funding
24 authors at 4 institutions in 2 countries.
Funding
Abstract
The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis. Metagenome analysis revealed K. heterogenica or K. weizmannii presence among human commensals. Our results reveal competitive fungal commensalism within the intestinal microbiota, independent of bacteria and immune responses, that could bear potential therapeutic value for the management of C. albicans-mediated diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.